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Published on: March 14, 2013
Early Post-operative Hemodynamic Perturbation Associated with Topiramate-induced Metabolic Acidosis: A Case Report
Shalendra Singh1, Sujoy Banik2, Keshav Goyal1
1Dept of Neuroanaesthesiology and Critical Care, AIIMS, New Delhi, India.
Abstract:
Topiramate is a potent antiepileptic drug with multiple modes of action including inhibition of carbonic anhydrase activity. Inhibition of this enzyme predisposes to non-anion gap metabolic acidosis which has been amply described in the literature. However, the severity is yet to be well defined. We encountered a case of topiramate-induced non-anion gap metabolic acidosis associated with hemodynamic perturbations in an 8-year-old child in the postoperative period.
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