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Updated: Jun 30, 2026
The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity
Anna A Krasilnikova1,2, Anastasiya O Solovieva1,2, Anton A Ivanov1,3
1Research Institute of Experimental and Clinical Medicine , 2 Timakova Str. , 630060 Novosibirsk , Russian Federation . Email: shtopy@niic.nsc.ru ; ; Tel: +7 383 330 92 53.
The novel rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] shows lower toxicity than related compounds. This improved safety profile is linked to its lower osmolality, making it a promising X-ray contrast agent.
Area of Science:
- Inorganic Chemistry
- Materials Science
- Biomedical Imaging
Background:
- Octahedral rhenium cluster compounds are promising X-ray contrast agents.
- Synthesis challenges arise from ligand hydrolysis, impacting compound properties.
- Toxicity of these agents is crucial for biomedical applications.
Purpose of the Study:
- To compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with related compounds.
- To investigate the role of ligand hydrolysis in the toxicity of rhenium cluster-based X-ray contrast agents.
- To elucidate the relationship between compound osmolality and observed toxicity.
Main Methods:
- Synthesis of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] and related compounds with fully hydrolyzed ligands.
- In vitro cytotoxicity assays.
- In vivo acute toxicity studies in animal models.
- Osmolality measurements of the compound solutions.
Main Results:
- Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] exhibited significantly lower cytotoxicity compared to compounds with fully hydrolyzed ligands.
- Acute in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] was considerably reduced.
- The observed toxicity differences correlate with the osmolality of the solutions, with lower osmolality correlating with lower toxicity.
Conclusions:
- The partially hydrolyzed ligand in Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] leads to reduced toxicity compared to fully hydrolyzed analogues.
- Lower osmolality of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions is a key factor in its improved safety profile.
- This finding supports the development of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] as a safer X-ray contrast agent.
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