Related Experiment Video
Updated: Feb 6, 2026

Assessment of the Metabolic Profile of Primary Leukemia Cells
Published on: November 21, 2018
Plasma cell leukemia
Shaylika Chauhan1, Priya Jaisinghani2, Jaivir Rathore3
1Department of Internal Medicine, Saint Peter's University Hospital, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
This case report details a rare instance of primary plasma cell leukemia (PCL) presenting atypically and rapidly progressing to multi-organ failure. It highlights the critical need for timely diagnosis and treatment of acute PCL.
Area of Science:
- Hematology
- Oncology
- Internal Medicine
Background:
- Primary plasma cell leukemia (PCL) is a rare and aggressive plasma cell dyscrasia.
- Atypical presentations of PCL can delay diagnosis and treatment.
- Rapid progression to multi-organ failure is a known, albeit severe, complication.
Observation:
- A rare case of PCL presented with atypical clinical manifestations.
- The patient's condition rapidly deteriorated, leading to life-threatening multi-organ failure.
Findings:
- The case challenges current diagnostic guidelines for PCL.
- Atypical presentations can mask or delay the diagnosis of acute PCL.
Implications:
- Prompt diagnosis and aggressive treatment are crucial for managing acute PCL.
- Further research into diagnostic markers and therapeutic strategies for PCL is warranted.
Related Concept Videos
Protein Buffers in Blood Plasma and Cells
Certain amino acids can exist in a zwitterion state at a...
Composition of Blood Plasma
Enlargement of the Plasma Membrane
Plasma Membrane in Bacteria and Archaea
Drug Distribution: Plasma Protein Binding
Fusion of Secretory Vesicles with the Plasma Membrane
In 1993, Jim Rothman proposed that the antiparallel pairing of vesicular and transmembrane SNAREs, or...

