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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Multiple sclerosis incidence in Tuscany from administrative data.

Daiana Bezzini1,2, L Policardo3, F Profili3

  • 1Department of Life Sciences, University of Siena, via Aldo Moro 2, 53100, Siena, (SI), Italy. daiana.bezzini@unisi.it.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|August 10, 2018
PubMed
Summary

This study found a high incidence rate of multiple sclerosis (MS) in Tuscany, Italy, using administrative data. The findings highlight the need for further validation of the case-finding algorithm for accurate MS epidemiology.

Keywords:
Administrative dataIncidenceItalyMultiple sclerosisSex ratioTuscany

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Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Italy has a high burden of multiple sclerosis (MS), with an estimated 110,000 prevalent cases in 2016.
  • Population-based studies and registries are ideal for epidemiological research, but administrative data offers a viable alternative for comprehensive population data.
  • Multiple sclerosis epidemiology in high-risk areas like Italy requires robust data collection methods.

Purpose of the Study:

  • To estimate the incidence of multiple sclerosis (MS) in Tuscany, Italy.
  • To utilize a validated case-finding algorithm based on administrative data for MS incidence estimation.
  • To provide insights into MS epidemiology in a high-risk Italian region.

Main Methods:

  • A validated case-finding algorithm using administrative data was employed.
  • Incident multiple sclerosis (MS) cases were identified from prevalent cases not previously recorded.
  • The date of the first MS-related claim served as the diagnosis incidence date for the period 2011-2015.

Main Results:

  • A total of 1147 incident multiple sclerosis (MS) cases were identified.
  • Annual incidence rates ranged from 5.60 per 100,000 in 2011 to 6.58 per 100,000 in 2015.
  • The incidence rates observed are comparable to other Italian regions.

Conclusions:

  • A high incidence rate of multiple sclerosis (MS) was observed in Tuscany, consistent with other Italian areas.
  • The high incidence, particularly in women, may contribute to the increasing prevalence of MS in Tuscany.
  • Further validation of the incident case-finding algorithm is planned to confirm findings and assess potential biases.