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[Hemolysis after aortic valve replacement (author's transl)].

A Dörig, M Rothlin, B J Messmer

    Thoraxchirurgie, Vaskulare Chirurgie
    |April 1, 1977
    PubMed
    Summary
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    This study compared hemolysis in patients with Björk-Shiley and Starr-Edwards aortic valve prostheses. While both showed low hemolysis when functioning correctly, LDH levels indicated less hemolysis with Björk-Shiley valves.

    Area of Science:

    • Cardiovascular Surgery
    • Biomaterials Science
    • Hematology

    Context:

    • Aortic valve replacement (AVR) is a common procedure to treat aortic valve disease.
    • Prosthetic heart valves, such as Björk-Shiley and Starr-Edwards, are used to restore valve function.
    • Hemolysis, the destruction of red blood cells, is a potential complication following AVR.

    Purpose:

    • To determine the rate of hemolysis in patients undergoing isolated aortic valve replacement with different prosthetic valves.
    • To identify the most reliable laboratory parameter for assessing hemolysis after AVR.
    • To compare the hemolytic potential of Björk-Shiley and Starr-Edwards prostheses, as well as unstented Fascia-lata valves.

    Summary:

    • Fifty patients undergoing isolated aortic valve replacement were evaluated for hemolysis using various hematologic and blood-chemical tests.

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  • Lactate dehydrogenase (LDH) was identified as the most reliable parameter for quantifying hemolysis.
  • Patients with Björk-Shiley prostheses exhibited lower average hemolysis (LDH 201 IU) compared to those with Starr-Edwards prostheses (LDH 273 IU).
  • Unstented Fascia-lata valves showed a degree of hemolysis directly correlated with their functional status.

    • Impact:

    • Provides comparative data on the hemolytic profiles of commonly used aortic valve prostheses.
    • Highlights LDH as a key biomarker for monitoring hemolysis post-AVR.
    • Suggests that Björk-Shiley prostheses may be associated with a lower rate of hemolysis compared to Starr-Edwards prostheses under normal function.
    • Emphasizes the importance of valve function in relation to hemolysis, particularly for bioprosthetic valves.