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In-hospital cardiovascular events after liver transplantation: predictors and long-term outcome

N T B Scholte1, M J Lenzen1, B van der Hoven2

  • 1Department of Cardiology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.

Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
|August 10, 2018
PubMed

Insights

Cardiovascular events (CVEs) affect 11% of liver transplant patients. Age, MELD score, and sinus tachycardia are key predictors of these early post-transplant complications.

Area of Science:

  • Cardiology
  • Hepatology
  • Transplantation Medicine

Background:

  • Liver transplantation is a successful treatment for end-stage liver disease.
  • Cardiovascular mortality is the leading cause of death after liver transplantation.
  • Early cardiovascular events (CVEs) are a significant concern in the postoperative period.

Purpose of the Study:

  • To determine the prevalence of early cardiovascular events (CVEs) after liver transplantation.
  • To identify independent predictors of in-hospital CVEs.
  • To analyze the impact of CVEs on short- and long-term outcomes.

Main Methods:

  • Retrospective study of 916 primary liver transplant recipients from 1986 to 2017.
  • Investigation of in-hospital CVE occurrence and associated risk factors.
  • Sub-analysis using echocardiography data for 597 patients.

Main Results:

  • The prevalence of CVEs was 11%.
  • Independent predictors for CVEs included higher age, higher MELD score, and sinus tachycardia.
  • Echocardiographic findings like larger left atrial diameter and higher E/E' ratio were associated with CVEs.

Conclusions:

  • Age, MELD score, and sinus tachycardia are significant predictors of CVEs post-liver transplantation.
  • Sinus tachycardia, often linked to acute liver failure and cirrhosis, is an independent risk factor.
  • Long-term survival in 30-day survivors was comparable between groups with and without CVEs.
Abstract

Keywords:
Cardiovascular eventsLiver transplantationPostoperative complicationsRisk factors

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