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Updated: Feb 6, 2026
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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
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Regional neuronal activity in patients with relapsing remitting multiple sclerosis
Annette Baumgartner1,2, Lars Frings3, Florian Schiller3
1Department of Neurology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Acta Neurologica Scandinavica
|August 10, 2018
Summary
Interferon-beta therapy alters brain glucose metabolism in relapsing remitting multiple sclerosis (RRMS) patients, affecting neuronal function. Fatigue and depression in untreated RRMS patients correlate with reduced neuronal activity.
Area of Science:
- Neuroscience
- Neurology
- Medical Imaging
Background:
- Interferon-beta is a standard treatment for relapsing remitting multiple sclerosis (RRMS).
- The precise effects of interferon-beta on neuronal activity in RRMS patients remain unclear.
Purpose of the Study:
- To investigate the impact of interferon-beta therapy on cerebral glucose metabolism in RRMS patients.
- To explore the relationship between clinical symptoms (fatigue, depression) and neuronal activity in untreated RRMS patients.
Main Methods:
- Utilized [18F]fluorodeoxyglucose positron emission tomography (FDG-PET) to measure cerebral metabolic rate of glucose (CMRglc).
- Assessed 15 RRMS patients before and after 6 months of interferon-beta therapy, alongside 10 healthy controls.
- Conducted clinical and neuropsychological assessments to evaluate fatigue and depression.
Main Results:
- No significant differences in absolute CMRglc were observed between RRMS patients and controls, or before and during treatment.
- Interferon-beta treatment led to decreased relative glucose metabolism in the cerebellum and increased metabolism in specific cortical and subcortical areas.
- In untreated patients, higher fatigue correlated with lower metabolism in the posterior cingulate cortex, and higher depression with lower metabolism in the superior temporal sulcus.
Conclusions:
- Interferon-beta treatment influences neuronal function in the cerebellum, cortex, and subcortical regions.
- Reduced neuronal activity in specific brain areas is associated with increased fatigue and depression in untreated RRMS patients.
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