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Updated: Feb 6, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

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The Role of Vascular Endothelial Growth Factor in Systemic Sclerosis

Victoria A Flower1,2, Shaney L Barratt3,4, Stephen Ward2

  • 1Royal National Hospital for Rheumatic Disease, Royal United Hospitals NHS Foundation Trusts, Bath, BA1 1RL United Kingdom.

Current Rheumatology Reviews
|August 10, 2018
PubMed

Insights

Systemic Sclerosis (SSc) involves autoimmunity, vasculopathy, and fibrosis. This review explores how Vascular Endothelial Growth Factor-A (VEGF-A) isoforms impact SSc, potentially guiding personalized treatments.

Area of Science:

  • Immunology
  • Vascular Biology
  • Fibrosis Research

Background:

  • Systemic Sclerosis (SSc) is characterized by autoimmunity, vasculopathy, and tissue remodeling.
  • Current SSc treatments often address these aspects separately.
  • Vascular Endothelial Growth Factor (VEGF) signaling is implicated in SSc pathogenesis.

Purpose of the Study:

  • To review the role of Vascular Endothelial Growth Factor (VEGF) in Systemic Sclerosis (SSc).
  • To explore how differential expression of Vascular Endothelial Growth Factor-A (VEGF-A) isoforms influences SSc vasculopathy and fibrosis.
  • To provide insight into SSc clinical heterogeneity and disease progression.

Main Methods:

  • Literature review focusing on VEGF and its isoforms in SSc.
  • Analysis of potential mechanisms linking VEGF-A splicing to SSc pathology.
  • Examination of emerging VEGF-targeted therapies for SSc.

Main Results:

  • Differential expression of VEGF-A splice isoforms may contribute to SSc vasculopathy and fibrosis.
  • VEGF-A isoform variations could explain clinical heterogeneity and disease progression in SSc.
  • Targeting VEGF signaling presents a potential therapeutic avenue for SSc.

Conclusions:

  • VEGF-A isoform expression is a key factor in SSc pathogenesis, affecting vasculopathy and fibrosis.
  • Understanding VEGF-A splicing offers insights into SSc heterogeneity and progression.
  • Targeting VEGF pathways, considering specific isoforms, may enable personalized SSc medicine.
Keywords:
Systemic sclerosis (scleroderma)VEGF-AVEGF-A165banti-angiogenicfibrosispathogenesispro-fibroticvascular endothelial growth factorvasculopathy.

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