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Plaquing of Herpes Simplex Viruses
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All Aboard! Enteric Viruses Travel Together.

Carmen Mirabelli1, Christiane E Wobus1

  • 1Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.

Cell Host & Microbe
|August 10, 2018
PubMed
Summary

Virus clusters cloaked in vesicles found in feces are more infectious than individual virus particles. This discovery challenges the traditional view of virus transmission, particularly for rotavirus and norovirus.

Area of Science:

  • Virology
  • Microbiology
  • Infectious Diseases

Background:

  • Individual virus particles were historically considered the primary infectious unit.
  • Understanding virus transmission mechanisms is crucial for public health.

Purpose of the Study:

  • To investigate alternative forms of virus particles involved in transmission.
  • To determine if clustered viruses exhibit different infectious potential.

Main Methods:

  • Analysis of fecal samples from infected hosts.
  • Microscopic examination to identify virus structures.
  • Infectivity assays to compare different viral forms.

Main Results:

  • Discovery of rotavirus and norovirus clusters enclosed within vesicles.

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  • Vesicle-cloaked virus clusters demonstrated higher infectivity than free virus particles.
  • Evidence suggests these clusters are significant in fecal-oral transmission.

    • Conclusions:

    • Virus clusters, particularly those within vesicles, represent a more infectious unit than previously thought.
    • This finding necessitates a re-evaluation of viral infectiousness and transmission models.
    • Implications for understanding and controlling rotavirus and norovirus spread.