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Immune checkpoint inhibitors and the development of granulomatous reactions

Christine M Cornejo1, Paul Haun1, Joseph English2

  • 1Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania.

Journal of the American Academy of Dermatology
|August 10, 2018
PubMed

Immune checkpoint inhibitors (ICPIs) have emerged as a frontline treatment for a growing list of malignancies. Disruption of the negative regulatory immune checkpoints by ICPIs has been associated with many immune-related adverse events. Granulomatous reactions, such as sarcoidosis-like reactions, granulomatous panniculitis, granuloma annulare, and granulomatous dermatitis, are uncommon but increasingly recognized immune-related adverse events seen in patients treated with ICPIs. The frequency and significance of these eruptions, including whether they portend responsiveness to treatment, remain unclear. Additionally, understanding the role of immune checkpoint blockade in these reactions may provide mechanistic insight into the relevant signaling pathways involved in sarcoidosis and other granulomatous disorders.

Keywords:
CTLA4PD-1checkpoint inhibitorsgranuloma annularegranulomatousgranulomatous dermatitisgranulomatous panniculitisimmune-related adverse eventssarcoidosis

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