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The role of melatonin, a multitasking molecule, in retarding the processes of ageing

Maryam Majidinia1, Russel J Reiter2, Seyed Kazem Shakouri3

  • 1Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran.

Ageing Research Reviews
|August 10, 2018
PubMed

Insights

Melatonin, a key hormone, shows promise in combating biological ageing. Its antioxidant and anti-inflammatory properties may mitigate age-related cellular damage and improve organ function.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Endocrinology

Background:

  • Biological ageing involves cellular dysfunction and increased vulnerability.
  • Ageing mechanisms include oxidative stress, mitochondrial dysfunction, and inflammation.
  • Melatonin is a crucial hormone regulating circadian rhythms and possessing antioxidant properties.

Purpose of the Study:

  • To review the protective effects of melatonin against ageing-induced molecular and structural changes.
  • To summarize current findings on melatonin's role in ageing across different tissues and organs.

Main Methods:

  • Literature review of recent scientific reports and studies.
  • Categorization of melatonin's protective effects into four main areas.
  • Synthesis of data on melatonin's function in ageing models.

Main Results:

  • Melatonin demonstrates multifaceted protective effects against ageing.
  • These effects include antioxidant, anti-inflammatory, and cellular repair modulation.
  • Evidence suggests melatonin can lessen the molecular and structural consequences of ageing.

Conclusions:

  • Melatonin acts as a significant anti-ageing agent.
  • Its diverse functions offer potential therapeutic strategies for age-related decline.
  • Further research is warranted to fully elucidate melatonin's anti-ageing potential in various physiological contexts.
Keywords:
AgeingCircadian rhythmInflammationMetabolic sensingMitochondria dysfunctionOxidative stress

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