Long-term Outcomes after Transplant Renal Artery Stenosis Surgery

The occurrence of transplant renal artery stenosis (TRAS) ranges from 1 to 23% and is associated with resistant hypertension, volume overload, graft dysfunction, and poor long-term graft and patient survival. Enhancing graft availability with expanded criteria donors results in the transplantation of kidneys with atherosclerotic arteries, increasing the risk of vascular complications. Although endovascular management is the first-line strategy in this context, in some patients, surgery has to be considered. We report the experience and long-term follow-up of TRAS surgery in a French kidney transplantation center. Between 2004 and 2009, 10 patients with postoperative TRAS, considered unfit for an endovascular procedure by a multidisciplinary team, were addressed for surgery. Mean time from transplantation to surgery was 139.8 ± 136.4 days. Clinical indications were oliguria, anuria, or acute decrease in urine output (n = 5), resistant hypertension (n = 4), and persistence of a decreased allograft function (n = 1). Imaging-revealed ostial stenosis is associated with external iliac artery stenosis (n = 3) or early bifurcation (n = 2), and kinking (n = 5). Revascularization techniques consisted in a great saphenous vein bypass (n = 5) and internal iliac artery anastomosis (n = 5). In the postoperative period, there was no graft loss, but 2 patients required hemodialysis during the first week. Mean follow-up was 9.8 ± 2.1 years. One patient lost his graft 10.3 years after transplantation due to chronic rejection, and 1 patient needed endovascular dilation. There was no graft loss at 5 years. Blood pressure was controlled in all patients. Surgical intervention for TRAS is safe and effective on graft survival and graft function and has to be considered for patients unsuitable for endovascular repair.