Terezine E, bioactive prenylated tryptophan analogue from an endophyte of Centaurea stoebe
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Updated: Feb 6, 2026

Establishing Fungal Entomopathogens as Endophytes: Towards Endophytic Biological Control
Published on: April 11, 2013
Randa Abdou1,2, Samah Shabana3, Mostafa E Rateb4,5
1Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Abstract:
Fungal endophytes are considered promising sources of new bioactive natural products. In this study, a Mucor sp. has been isolated as an endophyte from the medicinal plant Centaurea stoebe. Through bioactivity-guided fractionation, the isolation of the new bioactive terezine E in addition to the previously reported 14-hydroxyterezine D was carried out. The isolated compounds were fully characterised by HRESIMS and 1D and 2D NMR analyses. Both compounds exhibited potent antiproliferative activity against K-562 and HUVEC cell lines and antifungal efficacy against the tested fungal strains.
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