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Updated: Feb 6, 2026
Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
Published on: April 8, 2020
Spectroscopic insight into supramolecular assemblies of boric acid derivatives and β-cyclodextrin
Artur Kasprzak1, Krzysztof M Borys1, Sergey Molchanov1
1Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664, Warsaw, Poland.
Abstract:
Interactions of select boric acid derivatives with β-cyclodextrin were investigated. All products were obtained employing the grinding-induced mechanochemical approach. It was found that phenylboronic acid, benzoxaborole and boric acid form non-covalent, hydrogen bonding-based systems with β-cyclodextrin, whereas catechol and pinacol esters of phenylboronic acid as well as ferroceneboronic acid form host-guest inclusion complexes. The interactions were probed using spectroscopic methods: 1H NMR, 1H-1H ROESY NMR, 1H DOSY NMR, FT-IR. Association constant values were evaluated by 1H DOSY NMR. The highest association constant was found for boric acid (117.5 ± 2.5 M-1), whilst the lowest for benzoxaborole (14.8 ± 0.3 M-1). The study shows the influence of boron compound structure on the nature of the assembly formed with β-cyclodextrin, laying up the basis for future work with such supramolecular systems.
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