Related Experiment Video

Updated: Feb 6, 2026

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

580

Sleep disturbances and their impact in pediatric cystic fibrosis

Aarti Shakkottai1, Louise M O'Brien2, Samya Z Nasr3

  • 1Sleep Disorders Center and Department of Neurology, Michigan Medicine, Ann Arbor, MI, USA; Pediatric Pulmonology, Department of Pediatrics and Communicable Diseases, Michigan Medicine, Ann Arbor, MI, USA.

Sleep Medicine Reviews
|August 11, 2018
PubMed

Insights

Children with cystic fibrosis (CF) often experience poor sleep quality, including reduced sleep efficiency and frequent arousals. This review explores the impact of these sleep disturbances on CF health outcomes.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Cystic Fibrosis Research

Background:

  • Cystic fibrosis (CF) is a multi-system genetic disorder leading to chronic respiratory infections, cough, and malabsorption.
  • Patients with CF frequently report poor sleep quality, but objective data and clinical implications are limited.
  • Existing research indicates reduced sleep efficiency and frequent arousals in CF patients, alongside sleep-related gas exchange abnormalities.

Purpose of the Study:

  • To review current knowledge on sleep disturbances in children with cystic fibrosis.
  • To explore the clinical implications of sleep abnormalities in pediatric CF patients.
  • To highlight emerging evidence on the relationship between sleep problems and CF-specific outcomes.

Main Methods:

  • Literature review synthesizing existing studies on sleep in pediatric cystic fibrosis.
  • Analysis of objective sleep data, including sleep efficiency and arousals.
  • Examination of polysomnography findings and gas exchange during sleep.

Main Results:

  • Children with CF exhibit objectively measured poor sleep efficiency and frequent arousals.
  • Abnormalities in gas exchange during sleep are present in this population.
  • The impact of these sleep issues on health and quality of life is not well understood.

Conclusions:

  • Sleep disturbances are a significant issue for children with cystic fibrosis.
  • Further research is needed to understand the impact of sleep problems on lung function and other disease-specific outcomes.
  • Clinical practice should consider addressing sleep quality in the management of pediatric CF patients.

Keywords:
AdolescentsChildrenCystic fibrosisHypoxemiaObstructive sleep apneaSleepSleep-disordered breathing

More Related Videos

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis07:56

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

3.3K
Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes03:53

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes

Published on: April 19, 2024

1.2K

Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
888
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
545
Ecological Disturbance02:26

Ecological Disturbance

An ecological disturbance is a temporary disruption in the environment resulting from abiotic, biotic, or anthropogenic factors, causing a pronounced change in an ecosystem. The impact of an ecological disturbance, which can depend on its intensity, frequency, and spatial distribution, plays a significant role in shaping the species diversity within the ecosystem.
21.1K
Disturbances in Heart Rhythm01:29

Disturbances in Heart Rhythm

Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
3.0K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
942
Stages of Sleep01:22

Stages of Sleep

Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.5K