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Updated: Feb 6, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

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Long-term outcomes of His bundle pacing in patients with heart failure with left bundle branch block

Weijian Huang1,2, Lan Su1,2, Shengjie Wu1,2

  • 1Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Heart (British Cardiac Society)
|August 11, 2018
PubMed

Insights

His bundle pacing (HBP) effectively corrects left bundle branch block (LBBB) in heart failure (HF) patients. This pacing method significantly improves heart function and reduces symptoms over the long term.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Management

Background:

  • Left bundle branch block (LBBB) is a common conduction abnormality in heart failure (HF) patients.
  • LBBB can worsen cardiac function and prognosis in HF.
  • His bundle pacing (HBP) is an alternative pacing strategy that may correct LBBB.

Purpose of the Study:

  • To evaluate the efficacy of HBP in correcting LBBB in HF patients.
  • To assess the long-term clinical outcomes of HBP in this population.

Main Methods:

  • Observational study of HF patients with typical LBBB indicated for pacing.
  • Permanent HBP leads implanted based on correction thresholds.
  • Assessment of pacing parameters, LVEF, LVESV, and NYHA Class during follow-up.

Main Results:

  • HBP acutely corrected LBBB in 97.3% of patients.
  • Permanent HBP was achieved in 75.7% of patients.
  • At 3-year follow-up, patients with permanent HBP showed significant improvements in LVEF, LVESV, and NYHA Class.

Conclusions:

  • Permanent His bundle pacing effectively corrects LBBB in heart failure patients.
  • HBP leads to significant long-term improvements in cardiac function and clinical status.
Abstract

Keywords:
cardiac arrhythmias and resuscitation scienceheart failurepacemakers

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