Related Experiment Video
Updated: Feb 6, 2026

A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
Published on: April 30, 2020
Eighty-two-year-old man with a systolic murmur
Daniel F Kupsky1, Karthikeyan Ananthasubramaniam1, James Lee1
1Department of Medicine Division of Cardiology, Henry Ford Hospital Heart and Vascular Institute, Detroit, Michigan, USA.
Insights
This clinical case study highlights severe mitral stenosis in an elderly male patient undergoing cardiac risk evaluation. Echocardiography revealed characteristic Doppler findings indicative of this significant valvular heart disease.
Area of Science:
- Cardiology
- Cardiac Imaging
- Valvular Heart Disease
Background:
- Pre-operative cardiac risk assessment is crucial for elderly patients with comorbidities undergoing non-cardiac surgery.
- The patient presented for evaluation prior to resection of a small bowel gastrointestinal stromal tumour.
- He had a history of coronary artery bypass surgery, hypertension, and a low activity level.
Observation:
- Physical examination revealed a 2/6 systolic murmur at the apex.
- Electrocardiogram (ECG) showed normal sinus rhythm.
- Transthoracic echocardiography was performed for further cardiac evaluation.
Findings:
- Echocardiographic Doppler tracings of the mitral valve (Figure 1A) demonstrated findings consistent with severe mitral stenosis.
- Tricuspid valve Doppler (Figure 1B) was also analyzed.
Implications:
- Accurate diagnosis of severe mitral stenosis is critical for surgical planning and patient management.
- This case underscores the importance of echocardiography in identifying significant valvular heart disease in asymptomatic patients.
- Management strategies must address both the oncological and cardiovascular conditions.
Clinical Introduction:
An 82-year-old man with a history of coronary artery bypass surgery, hypertension and small bowel gastrointestinal stromal tumour underwent cardiac risk evaluation prior to surgical resection of his tumour. He was asymptomatic from a cardiovascular perspective, but his activity level was less than four metabolic equivalents. Physical examination was notable for a 2/6 systolic murmur at the apex. ECG showed sinus rhythm. A transthoracic echocardiogram was performed (figure 1 and online supplementary video 1).DC1SP110.1136/heartjnl-2018-313413.supp1Supplementary file 1 heartjnl;104/22/1887/F1F1F1Figure 1Transthoracic echocardiography. (A) Mitral valve continuous wave Doppler and (B) tricuspid valve continuous wave Doppler.
Question:
The findings in figure 1 are most likely due to which of the following?Atrioventricular conduction block.Acute severe aortic regurgitation.Patent ductus arteriosus.Atrial flutter.Severe mitral stenosis.
More Related Videos
10:20Right Ventricular Systolic Pressure Measurements in Combination with Harvest of Lung and Immune Tissue Samples in Mice
Published on: January 16, 2013
11:19Label-Free Immunoprecipitation Mass Spectrometry Workflow for Large-scale Nuclear Interactome Profiling
Published on: November 17, 2019