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Calciphylaxis in a dialysis patient successfully treated with high-dose vitamin K supplementation
Daniel Christiadi1, Richard F Singer1,2
1Canberra Hospital Renal Unit, Garran, ACT, Australia.
Abstract:
Calciphylaxis has high mortality. Vitamin K deficiency is common in haemodialysis patients and may be a trigger for calciphylaxis due to its role in activating matrix Gla protein (a tissue inhibitor of calcification). We report the case of a 43-year-old female haemodialysis patient who developed calciphylaxis. Two months prior to the diagnosis she was found to have an undetectable plasma vitamin K concentration. The calciphylaxis completely resolved with vitamin K supplementation and an increase in haemodialysis frequency. She did not receive sodium thiosulphate or bisphosphonates. Supplementation of vitamin K in deficient patients may improve the outcome of this condition.
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