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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease II: Clinical Manifestations01:24

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease IV: Nursing Management01:18

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
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Polyprotic Acids03:38

Polyprotic Acids

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Acids are classified by the number of protons per molecule that they can give up in a reaction. Acids such as HCl, HNO3, and HCN that contain one ionizable hydrogen atom in each molecule are called monoprotic acids. Their reactions with water are:
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COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
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Related Experiment Video

Updated: Feb 6, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Ascorbic acid: a promising agent in chronic kidney disease?

Salih Karahan1, Baris Afsar2, Mehmet Kanbay3

  • 1Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.

Clinical Kidney Journal
|August 11, 2018
PubMed
Summary
This summary is machine-generated.

Asymmetric dimethylarginine (ADMA) is linked to poor outcomes in chronic kidney disease (CKD). Ascorbic acid may improve outcomes by reducing oxidative stress and ADMA levels in CKD patients.

Keywords:
ascorbic acidcardiovascular diseaseinflammation

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Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase.
  • ADMA is associated with endothelial dysfunction and adverse outcomes in chronic kidney disease (CKD).
  • Oxidative stress and inflammation are prevalent in CKD, contributing to atherosclerosis and cardiovascular events.

Purpose of the Study:

  • To investigate the potential of ascorbic acid as a therapeutic agent in CKD.
  • To evaluate the effect of ascorbic acid on oxidative stress and ADMA levels in CKD patients.

Main Methods:

  • This study focuses on the biochemical and physiological effects of ascorbic acid in the context of CKD.
  • Analysis of ADMA levels and markers of oxidative stress.

Main Results:

  • Ascorbic acid demonstrated potential in reducing oxidative stress.
  • Ascorbic acid may lead to a decrease in ADMA levels.

Conclusions:

  • Ascorbic acid shows promise for improving outcomes in CKD patients.
  • Targeting oxidative stress and ADMA with ascorbic acid could be a beneficial strategy in managing CKD complications.