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Updated: Feb 6, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Ascorbic acid: a promising agent in chronic kidney disease?
Salih Karahan1, Baris Afsar2, Mehmet Kanbay3
1Department of Medicine, Koc University School of Medicine, Istanbul, Turkey.
Abstract:
Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, is related with impaired endothelial function and poor outcomes in chronic kidney disease (CKD) patients. In addition, oxidative stress and inflammation are also a common problem in CKD patients, and both have an important role in the development and progression of atherosclerosis and increased cardiovascular events in CKD. Ascorbic acid might be a promising agent in CKD for improving outcome by decreasing oxidative stress and ADMA levels.
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