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Activating transcription factor 3 in cardiovascular diseases: a potential therapeutic target

Heng Zhou1,2,3, Ning Li1,2,3, Yuan Yuan1,2,3

  • 1Department of Cardiology, Renmin Hospital of Wuhan University, JieFang Road 238, Wuhan, 430060, People's Republic of China.

Basic Research in Cardiology
|August 11, 2018
PubMed

Insights

Activating transcription factor 3 (ATF3) plays a key role in cardiovascular diseases (CVDs). Understanding ATF3's function offers potential new therapeutic strategies for heart conditions.

Area of Science:

  • Molecular Biology
  • Cardiology
  • Genetics

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of mortality.
  • Transcriptional factors critically regulate cellular functions and disease development.
  • Activating transcription factor 3 (ATF3) is an adaptive-response gene within the ATF/cAMP responsive element-binding (CREB) family.

Purpose of the Study:

  • To review the multifaceted role of ATF3 in various cardiovascular pathologies.
  • To explore ATF3 as a potential therapeutic target for CVDs.

Main Methods:

  • Literature review focusing on ATF3's involvement in cardiac hypertrophy, heart failure, atherosclerosis, ischemic heart diseases, hypertension, and diabetes mellitus.
  • Analysis of ATF3's function as a transcriptional regulator (repressor/activator) through homodimers or heterodimers.

Main Results:

  • Dysfunctional ATF3 expression is linked to inflammation, apoptosis, oxidative stress, and endoplasmic reticulum stress.
  • ATF3's role is implicated in the pathogenesis of major cardiovascular conditions.

Conclusions:

  • Appropriate ATF3 expression is vital for cellular homeostasis.
  • Targeting ATF3 presents a promising avenue for novel therapeutic interventions in CVDs.
Keywords:
Activating transcription factor 3AtherosclerosisCardiac hypertrophyCardiovascular diseasesHeart failure

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