Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Borderline Personality Disorder01:25

Borderline Personality Disorder

627
Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
Genetic and Environmental Contributions
Borderline Personality...
627
Psychotherapy01:28

Psychotherapy

531
Psychotherapy is a versatile, nonmedical approach aimed at helping individuals address emotional, behavioral, and interpersonal issues to enhance their overall well-being. It can involve one-on-one sessions, couples counseling, or small group discussions with a therapist. The therapeutic process includes various techniques such as open discussion, interpretation of thoughts and behaviors, active listening, positive reinforcement, and role modeling. Psychotherapy aims to support individuals in...
531
Structural Protein Function01:56

Structural Protein Function

30.0K
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity.  In bones and teeth, it mineralizes to...
30.0K
Structural Protein Function01:56

Structural Protein Function

3.3K
3.3K
Interpersonal Psychotherapy01:25

Interpersonal Psychotherapy

389
Interpersonal psychotherapy (IPT) is a structured, time-limited therapeutic approach initially developed to treat depression. It integrates key concepts from psychodynamic, humanistic, and cognitive-behavioral therapies, making it a uniquely eclectic framework. The therapy is rooted in the interpersonal theories of Adolph Meyer and Harry Stack Sullivan, as well as John Bowlby's attachment theory, and focuses on the interplay between interpersonal relationships and emotional well-being.
389
Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.3K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The functional neurobiology of dispositions towards negative emotions.

Nature communications·2026
Same author

Affective neural signatures do not distinguish women with emotion dysregulation from healthy controls: A mega-analysis across three task-based fMRI studies.

Neuroimage. Reports·2025
Same author

Cooperative decision-making in borderline personality disorder: insights from a preregistered study using a comprehensive economic task battery.

Borderline personality disorder and emotion dysregulation·2025
Same author

The functional neurobiology of negative affective traits across regions, networks, signatures, and a machine learning multiverse.

bioRxiv : the preprint server for biology·2025
Same author

Understanding and breaking the intergenerational cycle of abuse in families enrolled in routine mental health services: study protocol for a randomized controlled trial and two non-interventional trials investigating mechanisms of change within the UBICA II consortium.

Trials·2021
Same author

Oxytocin and social anxiety: Interactions with sex hormones.

Psychoneuroendocrinology·2021
Same journal

[Psychotropic drug research in Germany: challenges of early benefit assessment and precision psychiatry].

Der Nervenarzt·2026
Same journal

[When brain abscesses run in the family…].

Der Nervenarzt·2026
Same journal

[Digital health applications and adherence in depression: a qualitative study from the perspective of healthcare providers].

Der Nervenarzt·2026
Same journal

Der Nervenarzt·2026
Same journal

[Rare genetic diseases with frequent mental symptoms].

Der Nervenarzt·2026
Same journal

Der Nervenarzt·2026
See all related articles

Related Experiment Video

Updated: Feb 6, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

13.2K

[Borderline personality : Alterations to brain structure and function through psychotherapy].

C Schmahl1, I Niedtfeld2, S C Herpertz3

  • 1Klinik für Psychosomatik und Psychotherapeutische Medizin, Zentralinstitut für Seelische Gesundheit, J5, 68159, Mannheim, Deutschland. christian.schmahl@zi-mannheim.de.

Der Nervenarzt
|August 11, 2018
PubMed
Summary
This summary is machine-generated.

Psychotherapy for borderline personality disorder (BPD) improves emotion regulation by modulating brain activity, particularly in frontolimbic circuits. Successful treatment, like Dialectical Behavior Therapy (DBT), reduces amygdala hyperactivity.

Keywords:
AmygdalaDialectical Behavior TherapyEmotion regulationImaging studiesNeurofeedback

More Related Videos

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

27.0K
Personalized Needles for Microinjections in the Rodent Brain
10:06

Personalized Needles for Microinjections in the Rodent Brain

Published on: January 24, 2018

11.8K

Related Experiment Videos

Last Updated: Feb 6, 2026

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder
09:55

Use of a Psychophysiological Script-driven Imagery Experiment to Study Trauma-related Dissociation in Borderline Personality Disorder

Published on: March 8, 2018

13.2K
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

27.0K
Personalized Needles for Microinjections in the Rodent Brain
10:06

Personalized Needles for Microinjections in the Rodent Brain

Published on: January 24, 2018

11.8K

Area of Science:

  • Neuroscience
  • Psychiatry
  • Psychology

Background:

  • Borderline personality disorder (BPD) is characterized by difficulties in emotion regulation.
  • Several psychotherapeutic methods exist for BPD, focusing on enhancing emotional control.
  • Emerging research investigates the neural underpinnings of emotion regulation and therapy-induced changes.

Purpose of the Study:

  • To review neuroimaging studies examining emotion regulation in BPD before and after psychotherapy.
  • To understand the brain changes associated with successful BPD treatment.

Main Methods:

  • Systematic review of functional and structural neuroimaging studies.
  • Analysis of data on emotion regulation mechanisms and psychotherapeutic interventions.

Main Results:

  • Clinical improvement in BPD correlates with altered brain structure and function.
  • Frontolimbic circuits (amygdala, insula, ACC, prefrontal areas) are implicated in these changes.
  • Dialectical Behavior Therapy (DBT) is associated with reduced amygdala hyperactivity.

Conclusions:

  • Observed brain changes suggest enhanced emotion regulation capacities in BPD patients post-therapy.
  • Psychotherapy can modulate disturbed emotion regulation processes in BPD.
  • Long-term sustainability of these improvements requires further investigation.