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The roles of the COX2/PGE2/EP axis in therapeutic resistance

Dali Tong1, Qiuli Liu1, Lin-Ang Wang1

  • 1Department of Urology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, 10#, Changjiang Zhilu, Yuzhong District, Chongqing, 400042, People's Republic of China.

Cancer Metastasis Reviews
|August 11, 2018
PubMed

Insights

Understanding the COX2/PGE2/EP axis is key to overcoming cancer therapeutic resistance. This review explores its role in cancer stem cells, EMT, and immunity, and discusses targeted drugs.

Area of Science:

  • Oncology
  • Cancer Research
  • Molecular Biology

Background:

  • Therapeutic resistance is a major obstacle in cancer treatment.
  • Mechanisms include cancer stem cell repopulation, epithelial-mesenchymal transition (EMT), inflammation, and immunosuppression.
  • The COX2/PGE2/EP axis is implicated in tumor progression and therapeutic resistance.

Purpose of the Study:

  • To review the role of the COX2/PGE2/EP axis in cancer therapeutic resistance.
  • To focus on its involvement in cancer stem cell repopulation, EMT, and anti-cancer immunity.
  • To summarize drugs targeting the COX2/PGE2/EP axis and their mechanisms.

Main Methods:

  • Literature review of studies on the COX2/PGE2/EP axis and cancer resistance.
  • Analysis of signaling pathways involved in cancer stem cell repopulation, EMT, and immune evasion.
  • Compilation of information on existing therapeutic compounds targeting the axis.

Main Results:

  • The COX2/PGE2/EP axis significantly contributes to therapeutic resistance.
  • It influences cancer stem cell survival, promotes EMT, and suppresses anti-cancer immunity.
  • Various compounds targeting this axis are under investigation.

Conclusions:

  • Targeting the COX2/PGE2/EP axis offers potential strategies to overcome cancer therapeutic resistance.
  • Understanding these mechanisms may lead to additive or synergistic therapeutic effects.
  • Further research can guide the development of novel treatments with minimal adverse effects.
Keywords:
COX2EPPGE2Therapeutic resistance

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