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[Palliative therapy concepts for pancreatic carcinoma]
M Brunner1, R Grützmann1, G F Weber2
1Klink für Allgemein- und Viszeralchirurgie, Universitätsklinikum, Friedrich-Alexander-Universität, Krankenhausstraße 12, 91054, Erlangen, Deutschland.
Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen
|August 11, 2018
Summary
Most pancreatic cancer patients require palliative therapy due to advanced or metastatic disease at diagnosis. Treatment focuses on symptom management, nutritional support, and individualized chemotherapy, avoiding palliative resection.
Area of Science:
- Oncology
- Gastroenterology
- Palliative Care
Background:
- Pancreatic ductal adenocarcinoma is frequently diagnosed at advanced or metastatic stages.
- Patients often require palliative therapy to manage symptoms and improve quality of life.
Purpose of the Study:
- To outline current palliative management strategies for advanced pancreatic ductal adenocarcinoma.
- To emphasize individualized treatment approaches based on patient condition and treatment side effects.
Main Methods:
- Review of interventional and operative measures for biliary and gastrointestinal obstruction.
- Description of pain, nutritional, and anticoagulant therapies.
- Discussion of individualized palliative chemotherapy selection.
Main Results:
- Interventional procedures can restore biliary and intestinal patency.
- WHO pain management, nutritional support, and anticoagulation are key supportive measures.
- Individualized palliative chemotherapy is recommended, considering patient status and drug toxicity.
Conclusions:
- Palliative care is essential for advanced pancreatic cancer.
- Current evidence does not support palliative resection.
- Radiochemotherapy and local ablative therapies are investigational.
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