Contact allergy in Danish children: Current trends
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Updated: Feb 6, 2026
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
Anne B Simonsen1,2, Majken H Foss-Skiftesvik2, Jacob P Thyssen2
1National Allergy Research Centre, Department of Dermatology and Allergy, University of Copenhagen, Herlev and Gentofte Hospital, Gentofte, Denmark.
Insights
Allergic contact dermatitis is common in children, with increasing rates of allergy to fragrances and isothiazolinones. However, nickel allergy has decreased in this pediatric population.
Area of Science:
- Pediatric dermatology
- Allergology
- Epidemiology
Background:
- Contact allergy is prevalent in children but often underdiagnosed.
- Monitoring trends in pediatric contact allergies is crucial due to evolving clinical relevance.
Purpose of the Study:
- To investigate changes in contact allergy and allergic contact dermatitis among Danish children.
- To compare current patch testing data with historical trends in pediatric patients.
Main Methods:
- Retrospective analysis of patch test data from the Danish National Database of Contact Allergy.
- Comparison of data from 2012-2016 with previously published findings.
Main Results:
- 1573 children and adolescents underwent patch testing between 2012 and 2016.
- 24.5% of patients showed at least one positive patch test reaction.
- Significant increases in fragrance and isothiazolinone allergies were observed, while nickel allergy prevalence decreased.
Conclusions:
- Allergic contact dermatitis remains a significant health issue in children.
- Certain allergens, such as fragrances and isothiazolinones, show increasing prevalence in pediatric contact allergies.
Background:
Contact allergy is common in children, but may be underdiagnosed. Importantly, the clinical relevance of specific allergies is subject to constant change, and it is therefore important to continuously monitor the trends and changes of contact allergies in the paediatric population.
Objectives:
To identify possible changes in contact allergy and allergic contact dermatitis among Danish children referred for patch testing.
Methods:
A retrospective study was performed based on patch test data from the Danish National Database of Contact allergy. The current data were compared with previously published data on Danish children referred for patch testing.
Results:
Between 2012 and 2016, 1573 children and adolescents were patch tested. Overall, 385 (24.5%) had at least 1 positive patch test reaction. The overall prevalence was similar in boys and girls, across age groups, and in patients with and without atopic dermatitis. Statistically significant increases in contact allergy to fragrances and isothiazoliones were seen, whereas a decrease in nickel allergy was found.
Conclusion:
Allergic contact dermatitis continues to be a common disease in children, and is even significantly increasing for some allergens.
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