Related Experiment Video

Updated: Feb 6, 2026

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
07:35

Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data

Published on: December 1, 2023

1.2K

CASC2: An emerging tumour-suppressing long noncoding RNA in human cancers and melanoma

Xin Yu1, Heyi Zheng1, Gary Tse2

  • 1Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Cell Proliferation
|August 11, 2018
PubMed

Insights

Long noncoding RNA (lncRNA) CASC2 shows tumor-suppressive functions in various cancers. Further research is needed to validate CASC2 as a prognostic biomarker for clinical use.

Area of Science:

  • Molecular oncology
  • RNA biology
  • Cancer genetics

Background:

  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their roles in cancer development.
  • Dysregulation of lncRNAs is a hallmark of tumorigenesis across various cancer types.
  • Cancer Susceptibility Candidate 2 (CASC2) is a lncRNA frequently downregulated in multiple cancers.

Purpose of the Study:

  • To investigate the tumor-suppressive functions of CASC2 in human cancers.
  • To explore the potential of CASC2 as a prognostic biomarker.
  • To consolidate existing evidence on CASC2's role in oncogenesis.

Main Methods:

  • Literature review and meta-analysis of studies investigating CASC2 expression and function in cancer.
  • Analysis of CASC2's molecular mechanisms, including microRNA sequestration and signaling pathway modulation.
  • Evaluation of CASC2's prognostic value in different cancer types.

Main Results:

  • CASC2 exhibits significant tumor-suppressive activity through mechanisms like sequestering oncogenic microRNAs and inhibiting Wnt/β-catenin signaling.
  • Downregulation of CASC2 is observed in endometrial, lung, gastric, and colorectal cancers.
  • Preliminary studies suggest CASC2's potential as a prognostic marker in sporadic cancer cases.

Conclusions:

  • CASC2 plays a crucial tumor-suppressive role in human cancers, including melanoma.
  • Further extensive research and validation are required to establish CASC2 as a reliable clinical prognostic biomarker.
  • CASC2 warrants investigation in additional cancer types to fully elucidate its therapeutic and diagnostic potential.
Keywords:
lncRNAmelanomaprognostic markertumour suppressor

More Related Videos

Isolation of Small Noncoding RNAs from Human Serum06:44

Isolation of Small Noncoding RNAs from Human Serum

Published on: June 19, 2014

18.6K
Working with Human Tissues for Translational Cancer Research07:48

Working with Human Tissues for Translational Cancer Research

Published on: November 26, 2015

10.4K

Related Concept Videos

Emerging Adulthood01:27

Emerging Adulthood

Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
700
Introduction Cardiac Emergencies01:30

Introduction Cardiac Emergencies

Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
374
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.1K
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
79.2K
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.8K
RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.7K