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Updated: Feb 6, 2026

Interictal High Frequency Oscillations Detected with Simultaneous Magnetoencephalography and Electroencephalography as Biomarker of Pediatric Epilepsy
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Comorbidity of Migraine and Epilepsy in Pediatrics: A Review

Jasna Jancic1, Vesna Djuric2, Boris Hencic2

  • 11 Clinic of Neurology and Psychiatry for Children and Youth, Medical Faculty, University of Belgrade, Serbia.

Journal of Child Neurology
|August 11, 2018
PubMed

Insights

Migraine and epilepsy share clinical features and treatments in children. Further research is needed to understand their shared causes and improve therapies for these chronic neurologic disorders.

Area of Science:

  • Neurology
  • Pediatrics

Background:

  • Migraine and epilepsy are chronic neurologic disorders with overlapping clinical symptoms.
  • Pediatric populations exhibit significant similarities between these two conditions.

Purpose of the Study:

  • To review and highlight the similarities between migraine and epilepsy in children.
  • To explore epidemiologic, pathophysiological, genetic, clinical, and pharmacologic aspects of their comorbidity.

Main Methods:

  • Literature review focusing on pediatric migraine and epilepsy.
  • Analysis of shared clinical features, genetic factors, and treatment strategies.

Main Results:

  • Migraine and epilepsy share commonalities in epidemiology, pathophysiology, genetics, and clinical presentation.
  • Pharmacologic treatments for migraine prophylaxis, including antiepileptic drugs and calcium channel blockers, show potential.
  • Nonpharmacologic interventions like dietary therapy, supplements, and vagal nerve stimulation are also considered.

Conclusions:

  • Further research is essential to elucidate the pathophysiological and genetic underpinnings of migraine and epilepsy comorbidity.
  • Randomized controlled trials are needed to evaluate both pharmacologic and nonpharmacologic treatments for improved therapeutic approaches.

Keywords:
childrencomorbidityepilepsymigraine

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