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Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

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ALDH as a Stem Cell Marker in Solid Tumors.

Mariel E Toledo-Guzmán^1,2, Miguel Ibañez Hernández¹, Ángel A Gómez-Gallegos^2,3

¹Departamento de Bioquimica, Laboratorio de Terapia Genica, Escuela Nacional de Ciencias Biologicas, Posgrado de Biomedicina y Biotecnologia Molecular, Instituto Politecnico Nacional, Mexico City, Mexico.

Current Stem Cell Research & Therapy

|August 11, 2018

Summary

This summary is machine-generated.

Aldehyde dehydrogenase (ALDH) is a key marker for cancer stem cells (CSCs). Inhibiting ALDH reduces CSC traits and enhances drug sensitivity, making it a promising therapeutic target.

Keywords:

Aldehyde dehydrogenase all-trans-retinoic acid cancer stem cell isozyme retinoic acid stemness.

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Area of Science:

Biochemistry
Oncology
Cell Biology

Background:

Aldehyde dehydrogenase (ALDH) plays roles in cellular detoxification and retinoic acid synthesis.
ALDH activity is linked to drug resistance and cancer stem cell (CSC) properties.
ALDH is utilized to identify and isolate CSC populations across various tumor types.

Purpose of the Study:

To review evidence of ALDH as a CSC marker in solid tumors.
To summarize the functional roles of ALDH in CSCs.
To discuss the dual role of ALDH in maintaining stemness versus promoting differentiation.

Main Methods:

Literature review of current evidence on ALDH in solid tumors.
Analysis of studies investigating ALDH inhibition and its effects.
Discussion of ALDH inhibitors as potential anti-cancer therapeutics.

Main Results:

ALDH is a validated marker for identifying CSCs.
ALDH inhibition reduces CSC traits like proliferation and invasion.
ALDH inhibition sensitizes cancer cells to drugs.

Conclusions:

ALDH and retinoic acid are promising therapeutic targets for cancer treatment.
Understanding ALDH's role in stemness and differentiation is crucial.
ALDH inhibitors represent a developing strategy in anti-cancer drug development.