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Biotin-tagged fluorescent sensor to visualize 'mobile' Zn2+ in cancer cells
Le Fang1, Giuseppe Trigiante, Christina J Kousseff
1The Joseph Priestley Building, School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Chemical Communications (Cambridge, England)
|August 11, 2018
Abstract:
A cancer cell-targeting fluorescent sensor has been developed to image mobile Zn2+ by introducing a biotin group. It shows a highly selective response to Zn2+in vitro, no toxicity in cellulo and images 'mobile' Zn2+ specifically in cancer cells. We believe this probe has the potential to help improve our understanding of the role of Zn2+ in the processes of cancer initiation and development.