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Related Experiment Videos

Group C rotaviruses in humans.

J C Bridger, S Pedley, M A McCrae

    Journal of Clinical Microbiology
    |April 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Atypical rotaviruses found in humans are related to porcine group C rotaviruses. This study identifies the first human cases of group C rotaviruses, with low antibody prevalence observed globally.

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    Area of Science:

    • Virology
    • Microbiology
    • Public Health

    Background:

    • Rotaviruses are a common cause of gastroenteritis in infants and young children.
    • While common rotavirus strains are well-characterized, atypical strains require further investigation.
    • Group C rotaviruses are primarily known to infect pigs.

    Purpose of the Study:

    • To characterize atypical rotaviruses detected in human feces.
    • To determine the relationship between these atypical human rotaviruses and known porcine rotaviruses.
    • To assess the prevalence of antibodies against group C rotaviruses in human populations.

    Main Methods:

    • Immunoelectron microscopy
    • Immunofluorescence assays
    • Genome profile and segment fingerprint analysis

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  • Dot-blot hybridization
  • Serological testing of human sera and immunoglobulin pools
  • Inoculation studies in gnotobiotic piglets

    • Main Results:

    • Atypical human rotaviruses demonstrated a clear relationship to group C porcine rotaviruses.
    • Antibody prevalence to group C rotaviruses was low in human sera and immunoglobulin pools from six countries.
    • Experimental inoculation of gnotobiotic piglets with a human isolate did not result in observable signs of infection.

    Conclusions:

    • The identified atypical human rotaviruses represent the first documented instances of group C rotaviruses in humans.
    • The findings suggest a potential zoonotic transmission or cross-species relationship for group C rotaviruses.
    • Further research is warranted to understand the public health implications and epidemiology of group C rotaviruses in humans.