Related Experiment Video

Updated: Feb 6, 2026

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
14:04

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents

Published on: March 25, 2016

15.9K

New perspectives in the therapeutic approach of peripheral T-cell lymphoma

Christian Gisselbrecht1, David Sibon2

  • 1Hôpital Saint Louis, Institut d'hématologie Paris Diderot University.

Current Opinion in Oncology
|August 11, 2018
PubMed
Abstract

Insights

New targeted drugs show promise for peripheral T-cell lymphoma (PTCL) subtypes, addressing poor prognosis with current treatments. Challenges remain in clinical trials for rare diseases.

Area of Science:

  • Hematology
  • Oncology
  • Immunology

Background:

  • Peripheral T-cell lymphoma (PTCL) encompasses diverse T-cell and NK-cell neoplasms with poor prognosis.
  • Current treatments like CHOP are insufficient, highlighting an unmet need for novel therapies.

Purpose of the Study:

  • To review the development and application of new therapeutic agents for PTCL.
  • To discuss recent advancements and challenges in PTCL treatment.

Main Methods:

  • Review of Phase 2 studies evaluating new drugs in relapsed/refractory PTCL.
  • Analysis of approved therapies including epigenetic modifiers, antifolates, and antibody-drug conjugates.
  • Examination of targeted agents and immunotherapies in specific PTCL subtypes.

Main Results:

  • Four agents approved: romidepsin, belinostat, pralatrexate, and brentuximab vedotin.
  • New combinations yielded disappointing results; targeted agents show promise in specific subtypes.
  • Brentuximab vedotin improves prognosis in relapsed anaplastic large-cell lymphoma; immune checkpoint inhibitors benefit NK/T lymphoma.

Conclusions:

  • Targeted drugs offer new therapeutic avenues for challenging PTCL cases.
  • Incremental progress is expected across different PTCL subtypes.
  • Conducting robust clinical trials for rare diseases remains a significant hurdle.

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.7K
Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma08:31

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

Published on: September 12, 2025

836

Related Concept Videos

Psychodynamic Perspectives on Personality01:27

Psychodynamic Perspectives on Personality

The psychodynamic perspective in psychology asserts that most personality functions operate unconsciously, outside of awareness. This means that the motives and emotions driving behavior often remain hidden, automatically buried in the unconscious mind as a defense mechanism to shield us from psychological distress. According to this theory, the unconscious mind contains thoughts, memories, and emotions that are too disturbing to face directly.
Psychodynamic theorists argue that unconscious...
1.6K
Criticisms of the Evolutionary Perspective01:23

Criticisms of the Evolutionary Perspective

In a study where individuals posing as strangers offered compliments and proposed casual sex to students, the responses differed significantly based on gender. Not a single woman accepted the proposal, while 70% of the men agreed. This outcome provides a useful scenario to explore through the lens of evolutionary psychology and social learning theory, highlighting the diverse perspectives on human sexual behaviors.
Evolutionary psychology provides one explanation for these findings, suggesting...
376
The Behavioral Perspective on Personality01:19

The Behavioral Perspective on Personality

Behaviorists view personality as primarily shaped by environmental reinforcements and consequences. According to this perspective, behavior is influenced by external stimuli, and individuals adjust their actions based on rewards and punishments. Over time, learning histories — accumulated patterns of reinforcement — play a significant role in shaping personality. Behaviors that lead to positive outcomes are reinforced, while those resulting in negative outcomes are diminished.
835
Social Cognitive Perspective on Personality01:30

Social Cognitive Perspective on Personality

Social cognitive perspectives on personality emphasize the importance of conscious awareness, beliefs, expectations, and goals in shaping behavior. These perspectives incorporate behaviorist principles, such as learning through reinforcement and conditioning, but extend beyond them by highlighting human reasoning and planning. Unlike traditional behaviorist views, social cognitive theory focuses on how individuals reflect on their past experiences and plan for future outcomes by considering...
1.0K
Therapeutic Index01:13

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.9K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.7K