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Updated: Feb 6, 2026
06:34
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
10.5K
Component-resolved diagnosis in allergic disease: Utility and limitations
Angel San Miguel-Rodríguez1, Alicia Armentia2, Sara Martín-Armentia3
1Research Support Unit, Hospital Universitario Río Hortega, Spain.
Summary
Component Resolved Diagnosis (CRD) offers detailed allergy insights for complex cases. This method analyzes specific IgE to 112 allergens, aiding diagnosis in patients with multiple or difficult-to-trace allergies.
Area of Science:
- Allergy and Immunology
- Molecular Diagnostics
Background:
- Component Resolved Diagnosis (CRD) is a microarray technique.
- It simultaneously analyzes specific IgE antibodies against 112 allergenic components.
- CRD is particularly useful for multi-sensitized or complex allergy patients.
Purpose of the Study:
- To review the Component Resolved Diagnosis (CRD) method.
- To evaluate its utility and limitations in diagnosing allergic diseases.
- To present experience with CRD in challenging cases like eosinophilic esophagitis, occupational asthma, and drug allergy.
Main Methods:
- Microarray-based analysis of specific IgE antibodies.
- Simultaneous detection of IgE against 112 distinct allergenic components.
- Application in patients with concomitant respiratory and food allergies.
Main Results:
- CRD provides detailed sensitivity patterns for individual allergens.
- The method is indicated for complex patients with multiple allergies.
- Experience in difficult etiologic diagnoses was reviewed.
Conclusions:
- Component Resolved Diagnosis (CRD) is a valuable tool for complex allergy diagnostics.
- It enhances diagnostic accuracy in patients with respiratory, food, and drug allergies.
- CRD aids in understanding sensitization profiles for better patient management.
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