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Mechanistic Pathways of Selenium in the Treatment of Graves' Disease and Graves' Orbitopathy
Michele Marinò1, Giovanna Rotondo Dottore1, Marenza Leo1
1Department of Clinical and Experimental Medicine, Endocrinology Units, University of Pisa and University Hospital of Pisa, Pisa, Italy.
Abstract:
Based on the role of oxidative stress in the pathogenesis of Graves' hyperthyroidism and Graves' orbitopathy, the use of the antioxidant agent selenium has been proposed and several studies on the subject have been conducted, both in vitro and in vivo. Whereas a true benefit related to the use of selenium in patients with Graves' hyperthyroidism has been questioned, its use in patients with mild Graves' orbitopathy is generally believed to be beneficial because of which selenium has entered in the clinical practice for this eye condition.
Insights
Selenium supplementation may benefit patients with mild Graves
Area of Science:
- Endocrinology and Metabolism
- Oxidative Stress Research
- Ophthalmology
Background:
- Graves' hyperthyroidism and Graves' orbitopathy are linked to oxidative stress.
- Selenium, an antioxidant, has been investigated for its potential therapeutic role.
Purpose of the Study:
- To evaluate the efficacy of selenium supplementation in managing Graves' disease.
- To specifically assess selenium's impact on Graves' hyperthyroidism and Graves' orbitopathy.
Main Methods:
- In vitro and in vivo studies were conducted.
- Clinical trials involving patients with Graves' hyperthyroidism and Graves' orbitopathy were analyzed.
Main Results:
- Evidence for selenium's benefit in Graves' hyperthyroidism is inconclusive.
- Selenium supplementation is generally considered beneficial for mild Graves' orbitopathy.
Conclusions:
- Selenium's role in Graves' hyperthyroidism requires further investigation.
- Selenium has been integrated into clinical practice for managing mild Graves' orbitopathy due to its perceived benefits.