Related Experiment Video
Updated: Feb 6, 2026
07:00
Targeting of Deep Brain Structures with Microinjections for Delivery of Drugs, Viral Vectors, or Cell Transplants
Published on: December 1, 2010
13.2K
Scaffolds as Structural Tools for Bone-Targeted Drug Delivery.
Riccardo Ferracini1, Isabel Martínez Herreros2, Antonio Russo3
1Department of Surgical Sciences, Orthopaedic Clinic-IRCCS A.O.U. San Martino, 16132 Genova, Italy. riccardoferraciniweb@gmail.com.
Pharmaceutics
|August 12, 2018
Summary
Scientists are developing advanced biomaterials for artificial bones to repair large bone defects. These innovative scaffolds enhance bone regeneration through targeted drug delivery, offering new hope for patients.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Bone regeneration is crucial for repairing defects from trauma or surgery.
- Current bone grafts have limitations, necessitating advanced substitutes.
- Materials science innovations are driving the development of artificial bone solutions.
Purpose of the Study:
- To review recent advances in materials science for bone defect repair.
- To highlight the role of biomaterials and tissue engineering in creating bone substitutes.
- To discuss scaffolds for targeted drug delivery in bone regeneration.
Main Methods:
- Review of current literature on biomaterials and tissue engineering for bone regeneration.
- Analysis of innovations in synthetic scaffold development.
- Discussion of targeted drug delivery systems within scaffolds.
Main Results:
- Materials science has yielded significant innovations in biomaterials for bone substitutes.
- Three-dimensional scaffolds from organic or inorganic materials are key for tissue engineering.
- Scaffolds incorporating drugs and growth factors show promise for inducing new bone formation.
Conclusions:
- Advanced biomaterials and tissue engineering are essential for creating effective bone substitutes.
- Synthetic scaffolds offer a promising approach for repairing large bone defects.
- Targeted drug delivery via scaffolds represents a significant advancement in bone regeneration strategies.
Related Concept Videos
01:55Bone Structure
51.8K
Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
51.8K
01:16Drug Delivery: Overview
879
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
879
01:18Drug Delivery: Enteral Route
1.8K
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
1.8K
01:29Drug Delivery: Parenteral Route
1.7K
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
1.7K
01:26Targets for Drug Action: Overview
10.4K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
10.4K
01:22Drug Delivery: Miscellaneous Routes
833
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
833