Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamic responses of electrically coupled systems.

N G Publicover

    The Journal of General Physiology
    |April 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    This study models electrical synaptic transmission in snail neurons using frequency responses. A mathematical model accurately predicts neuron coupling behavior and response delays.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    New Concepts for X-Ray, Soft X-Ray, and EUV Optical Instrumentation Including Applications in Spectroscopy, Plasma Diagnostics, and Biomedical Microscopy: A Status Report.

    Journal of X-ray science and technology·2011
    Same author

    Photon event distribution sampling: an image formation technique for scanning microscopes that permits tracking of sub-diffraction particles with high spatial and temporal resolutions.

    Journal of microscopy·2010
    Same author

    Imaging single cardiac ryanodine receptor Ca2+ fluxes in lipid bilayers.

    Biophysical journal·2003
    Same author

    Diffusion of single cardiac ryanodine receptors in lipid bilayers is decreased by annexin 12.

    Biophysical journal·2003
    Same author

    Development of a time-cycled volume-controlled pressure-limited respirator and lung mechanics system for total liquid ventilation.

    IEEE transactions on bio-medical engineering·2001
    Same author

    Titin: an elastic link between length and active force production in myocardium.

    Circulation·2001

    Area of Science:

    • Neuroscience
    • Computational Biology
    • Biophysics

    Background:

    • Electrical synaptic transmission is crucial for neural network function.
    • The freshwater snail Helisoma trivis provides a model for studying electrical synapses.
    • Characterizing frequency responses reveals insights into synaptic properties.

    Purpose of the Study:

    • To characterize electrical synaptic transmission using frequency response analysis.
    • To develop and validate a mathematical model for electrical synaptic transmission.
    • To investigate the relationship between electrical properties and response delays in coupled neurons.

    Main Methods:

    • Sinusoidal frequency (Bode) responses computed via Laplace transforms.
    • Analysis of responses to brief current stimuli.

    Related Experiment Videos

  • Development of a mathematical model for electrical synaptic transmission.
  • Estimation of frequency responses from presynaptic measurements.
  • Computation of coupled system responses using the principle of superposition.

    • Main Results:

    • Injected neuron frequency response: 20-dB/decade attenuation, 0 to -90 degree phase shift.
    • Coupled cell frequency response: 40-dB/decade attenuation, 0 to -180 degree phase shift.
    • Mathematical model accurately replicates measured frequency responses.
    • Electrical properties impose minimum delays in postsynaptic responses.
    • Postsynaptic response delays correlate with network electrical and anatomical parameters.

    Conclusions:

    • The study successfully characterized electrical synaptic transmission in Helisoma trivis neurons.
    • A validated mathematical model aids in understanding electrical synapse dynamics.
    • Electrical and anatomical properties significantly influence signal transmission delays.