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Updated: Feb 6, 2026

A Simple Dry Sectioning Method for Obtaining Whole-Seed-Sized Resin Section and Its Applications
Published on: January 23, 2021
Seven new resin glycosides from the seeds of Quamoclit × multifida
Masateru Ono1, Maako Azuchi2, Misato Ichio2
1School of Agriculture, Tokai University, 9-1-1 Toroku, Higashi-ku, Kumamoto, 862-8652, Japan. mono@agri.u-tokai.ac.jp.
Abstract:
Seven new resin glycosides, multifidins III (1)-IX (7), were isolated from the seeds of Quamoclit × multifida (syn. Q. sloteri House) (Convolvulaceae), along with five known glycosides, quamoclinic acid B methyl ester (8), operculin XIII (9), quamoclin I (10), QM-10 (11), and QM-12 (12). Their structures were determined on the basis of spectroscopic data and chemical evidence. These compounds were of two different types, i.e., those with macrolactone structures and those with non-macrolactone structures. Additionally, cytotoxic activity towards HL-60 human leukemia cells of 1, 2, 5, 8, 9, 11, and 12 was evaluated. Among them, macrolactone-type resin glycosides (jalapins), 1, 2, and 9, specifically demonstrated clear cytotoxic activity with IC50 values of 3.46, 14.7, and 10.9 μM, respectively.
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