Related Experiment Video
Updated: Feb 6, 2026

Production of Human CRISPR-Engineered CAR-T Cells
Published on: March 15, 2021
Production quality and human factors engineering: A systematic review and theoretical framework
Ahmet Kolus1, Richard Wells2, Patrick Neumann3
1Systems Engineering Department, King Fahd University of Petroleum & Minerals, KFUPM, Dhahran 31261, Saudi Arabia.
Human factors (HF) significantly impact manufacturing quality. Addressing HF in operations systems design, like workload and fatigue, can improve system quality performance by up to 86%.
Area of Science:
- Industrial Engineering
- Human Factors Engineering
- Operations Management
Background:
- Manufacturing operations systems (OS) design and management are critical for system quality performance.
- Human factors (HF) play a significant, yet often overlooked, role in the success of these operations.
- Existing literature lacks a systematic synthesis of the empirical evidence linking HF to quality outcomes in manufacturing.
Purpose of the Study:
- To systematically review and examine empirical evidence on the impact of human factors (HF) in manufacturing operations design and management on system quality performance.
- To identify specific HF aspects that act as quality risk factors in manufacturing operations systems (OS).
- To provide a conceptual framework explaining the linkage between HF and quality in manufacturing.
Main Methods:
- A systematic literature review was conducted.
- Empirical studies linking human factors to operations systems performance in manufacturing were identified and analyzed.
- Data were synthesized to map linkages between human-system fit and production quality.
Main Results:
- Seventy-three empirical studies were identified, establishing a link between HF and OS performance in manufacturing.
- Quality risk factors related to HF include aspects of product design, process design, and workstation design.
- Undesirable human effects such as workload, fatigue, and injury risks were associated with quality deficits.
- Forty-six percent of studies reported on HF improvement efforts, with quality improvements reaching up to 86%.
Conclusions:
- Human factors are integral to the quality performance of manufacturing operations systems.
- Identifying and mitigating HF-related quality risks through improved design and management is crucial for enhancing production quality.
- The study provides a framework for understanding and leveraging the HF-Quality linkage in manufacturing contexts.
Related Concept Videos
Review and Preview
Percentiles are a type of fractile that partition data into...
Review and Preview
Theoretical Foundations of Nursing Practice
Theories provide a perspective to assess patients' conditions and organize data and methods. They also assist in analyzing and interpreting information. They represent a...
Theoretical Approaches to Psychological Disorder
Biological approach
The biological approach posits that internal, organic factors are the primary causes of such disorders. This perspective emphasizes brain structure and function, genetic predispositions, and neurotransmitter imbalances. For example, schizophrenia has been associated with both genetic...
Random and Systematic Errors
Biopharmaceutical Factors Influencing Drug Product Design: Overview

