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Using Saccadometry with Deep Brain Stimulation to Study Normal and Pathological Brain Function
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Deep Brain Stimulation: Clinical Applications.

Darin D Dougherty1

  • 1Division of Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, CNY2612, 149 13th Street, Boston, MA 02129, USA.

The Psychiatric Clinics of North America
|August 13, 2018
PubMed
Summary
This summary is machine-generated.

Deep brain stimulation (DBS) shows promise for psychiatric conditions like OCD. However, controlled trials for treatment-resistant depression using DBS yielded negative results, necessitating further research into new approaches.

Keywords:
DBS in PsychiatryDeep brain stimulationMechanisms of DBSTreatment resistant depressionTreatment-refractory OCD

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Area of Science:

  • Neurology
  • Psychiatry

Background:

  • Deep brain stimulation (DBS) is a long-established neurological treatment for movement disorders.
  • Emerging research explores DBS applications for psychiatric conditions, including obsessive-compulsive disorder (OCD) and treatment-resistant depression (TRD).

Purpose of the Study:

  • To review the current applications and future directions of deep brain stimulation in psychiatric illness.
  • To evaluate the efficacy of DBS for treatment-refractory obsessive-compulsive disorder and treatment-resistant depression.

Main Methods:

  • Review of existing literature on deep brain stimulation in neurology and psychiatry.
  • Analysis of initial open-label studies and controlled trials for treatment-resistant depression.

Main Results:

  • Initial studies show positive outcomes for DBS in treatment-refractory obsessive-compulsive disorder.
  • Two published controlled trials for FDA approval of DBS for treatment-resistant depression were negative despite encouraging open-label results.

Conclusions:

  • Deep brain stimulation demonstrates potential for treating certain psychiatric disorders.
  • Further research is needed to optimize DBS for treatment-resistant depression, exploring novel trial designs, advanced targeting techniques like tractography, and closed-loop systems.