Related Experiment Video
Updated: Feb 6, 2026
Visualizing Scar Development Using SCAD Assay - An Ex-situ Skin Scarring Assay
Published on: April 28, 2022
Hysteroscopic repair of cesarean scar isthmocele
1Department of Obstetrics and Gynecology Mount Sinai Hospital & Women's College Hospital; and Department of Obstetrics & Gynecology, University of Toronto, Toronto, Ontario, Canada.
Objective:
To demonstrate an approach to the hysteroscopic repair of cesarean scar isthmocele and discuss its association with secondary infertility.
Design:
A step-by-step explanation of the procedure with surgical video footage.
Setting:
Academic medical center.
Patient(S):
Two patients undergoing hysteroscopic repair of symptomatic cesarean scar isthmoceles. Surgical candidates for this procedure include patients with a symptomatic isthmocele and a residual myometrial thickness of at least 3 mm confirmed with pre-operative imaging.
Intervention(S):
Operative hysteroscopy is performed using a step-wise approach: identification of relevant anatomy; resection of the cephalad edge of fibrosis; resection of the caudad edge of fibrosis; and ablation of the isthmocele base.
Main Outcome Measure(S):
Restoration of the contour between the uterine cavity and cervical canal.
Result(S):
Hysteroscopic resection of cesarean scar isthmocele is successfully performed in both cases presented. Postoperatively, both patients had resolution of their symptoms.
Conclusion(S):
The surgical approach presented in this video can result in the successful revision of a cesarean scar isthmocele. Current literature supports a role for hysteroscopic isthmoplasty in treating isthmocele-related abnormal uterine bleeding. However, more evidence is required on the safety of conceiving following hysteroscopic isthmoplasty, and its use in the setting of secondary infertility.
More Related Videos
Related Concept Videos
01:36Mismatch Repair
01:20Mismatch Repair
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
02:25Overview of DNA Repair
Chemically...
01:54Base Excision Repair
The first step of...
01:08Nucleotide Excision Repair
01:38Nucleotide Excision Repair
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...