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Interleukin (IL)-8 polymorphisms contribute in suicide behavior.

Rezvan Noroozi1, Mir Davood Omrani2, Seyed Abdulmajid Ayatollahi3

  • 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cytokine
|August 13, 2018
PubMed
Summary
This summary is machine-generated.

Genetic variations in the Interleukin (IL)-8 gene are linked to suicide behavior. Specific IL-8 gene variants, like the T allele of rs4073, show a strong association with suicide attempts, offering new insights into the biological underpinnings of suicide.

Keywords:
IL-8PolymorphismSuicide

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Immune dysregulation is implicated in suicide behavior.
  • Lower serum concentrations of Interleukin (IL)-8, a neuroprotective chemokine, are observed in individuals who have died by suicide.
  • Genetic factors may influence susceptibility to suicide behavior.

Purpose of the Study:

  • To investigate the association between single nucleotide polymorphisms (SNPs) in the IL-8 gene and suicide behavior.
  • To examine the role of specific IL-8 gene variants (rs4073, rs2227306, rs1126647) in individuals who attempted suicide, died by suicide, and controls.

Main Methods:

  • Genotyping of three IL-8 gene SNPs (rs4073, rs2227306, rs1126647) was performed.
  • Study groups included 229 suicide attempters (soft methods), 235 suicide victims, and 290 controls.
  • Statistical analyses, including allele and haplotype frequency comparisons and association modeling, were conducted.

Main Results:

  • The T allele of rs4073 was significantly more frequent in the suicide attempt group compared to control and completed suicide groups.
  • This SNP (rs4073) showed significant associations with suicide attempts in dominant and co-dominant models.
  • Specific haplotypes (TCA and ATA) of IL-8 SNPs were associated with completed suicide and different suicide attempt methods.

Conclusions:

  • The study provides evidence for the involvement of IL-8 gene polymorphisms in suicide behavior.
  • Genetic variations in IL-8 may represent a risk factor for suicide attempts and influence suicide methods.
  • Further research into IL-8's role in neuroprotection and suicide pathogenesis is warranted.