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Local inhibition of carbonic anhydrase does not decrease sweat rate.

Jeff Moore1, Sarah Northway1, Nicole Wells1

  • 1School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA, USA.

Journal of Basic and Clinical Physiology and Pharmacology
|August 13, 2018
PubMed
Summary
This summary is machine-generated.

Inhibiting carbonic anhydrase (CA) in sweat glands did not affect sweat rate during exercise in heat. This suggests previous findings of reduced sweating were due to systemic dehydration, not direct gland effects.

Keywords:
carbonic anhydrasedehydrationdiamoxiontophoresis

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Area of Science:

  • Physiology
  • Dermatology
  • Exercise Science

Background:

  • Carbonic anhydrase (CA) plays a role in various physiological processes, including potential involvement in eccrine sweat production.
  • Previous studies suggested CA inhibition reduces sweat rate, but systemic effects like dehydration were confounding factors.
  • Directly inhibiting CA in sweat glands offers a method to isolate its role in sweat production.

Purpose of the Study:

  • To measure the effect of directly inhibiting carbonic anhydrase (CA) in eccrine sweat glands on sweat rate during exercise in heat.
  • To differentiate the effects of local CA inhibition from systemic dehydration on sweat production.
  • To investigate the specific role of CA within the sweat gland itself.

Main Methods:

  • Ten healthy subjects participated in the study.
  • Subjects exercised in a heated environment.
  • Transdermal iontophoresis was used to administer acetazolamide (a CA inhibitor) or a placebo (distilled water) to the forearm.

Main Results:

  • The mean sweat rate at the acetazolamide-treated site was 0.63±0.36 μL/cm2/min.
  • The mean sweat rate at the distilled water (control) site was 0.59±0.31 μL/cm2/min.
  • There was no statistically significant difference in sweat rate between the two conditions (p>0.05).

Conclusions:

  • Direct inhibition of carbonic anhydrase in eccrine sweat glands via acetazolamide iontophoresis does not significantly alter sweat rate during exercise in the heat.
  • The findings suggest that previously reported decreases in sweat rate attributed to CA inhibition were likely caused by systemic dehydration.
  • This study highlights the importance of considering local versus systemic effects when investigating physiological responses to pharmacological interventions.