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Related Concept Videos

The Evidence for Evolution02:55

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Genetic variations accumulating within populations over generations give rise to biological evolution. Evolutionary changes can result in the formation of novel varieties and entire new species. These changes are responsible for the diverse forms of life inhabiting the planet. The evidence for evolution suggests that all living organisms descended from common ancestors.
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The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
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John H. Renwick first coined the term “synteny” in 1971, which refers to the genes present on the same chromosomes, even if they are not genetically linked. The species with common ancestry tend to show conserved syntenic regions. Therefore, the concept of synteny is nowadays used to describe the evolutionary relationship between species.
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The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
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Related Experiment Video

Updated: Feb 6, 2026

Modeling Human Cerebellar Development In Vitro in 2D Structure
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Development and Evolution of Cerebral and Cerebellar Cortex.

David C Van Essen, Chad J Donahue, Matthew F Glasser

    Brain, Behavior and Evolution
    |August 13, 2018
    PubMed
    Summary

    The study explains the evolution of cerebral and cerebellar cortex shapes using developmental processes like axonal tension. It also examines conserved myelin maps and challenges in mapping cortical areas across species.

    Keywords:
    CerebellumCerebral cortexDevelopmentEvolutionHumanNeuroanatomyNonhuman primateParcellation

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    Area of Science:

    • Neuroscience
    • Evolutionary Biology
    • Comparative Anatomy

    Background:

    • Cerebral and cerebellar cortex exhibit significant interspecies variation in size and convolutional complexity.
    • Understanding the developmental and evolutionary trajectories of these cortical structures is crucial for neuroscience.

    Purpose of the Study:

    • To explain the development and evolution of cerebral and cerebellar cortex anatomy and functional organization.
    • To propose developmental mechanisms, such as mechanical tension, underlying cortical shapes.
    • To analyze the evolutionary conservation of functional organization, specifically myelin content maps, across primate species.

    Main Methods:

    • Comparative analysis of anatomical and functional organization across species.
    • Examination of developmental processes, including mechanical tension along axons and dendrites.
    • Interspecies registration of cortical surface data to compare distinct areas and their evolutionary correspondence.

    Main Results:

    • Cortical shapes can be attributed to a few key developmental processes, notably mechanical tension.
    • Myelin content maps in the cerebral cortex are evolutionarily conserved in primates.
    • Proportions of sensory, cognitive, and other functional areas vary across species.

    Conclusions:

    • Developmental mechanics offer a parsimonious explanation for cortical folding patterns.
    • Functional organization, while conserved in some aspects, shows species-specific variations.
    • Interspecies registration is a powerful tool for studying cortical evolution, despite methodological challenges.