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Elevated extracellular trap formation and contact system activation in acute leukemia
Tae Yeul Kim1, Ja-Yoon Gu1, Hye Soo Jung1
1Department of Laboratory Medicine, Seoul National University College of Medicine, 101 Daehang-ro, Jongno-gu, Seoul, 03080, South Korea.
Journal of Thrombosis and Thrombolysis
|August 13, 2018
Summary
Leukemic cells release nuclear extracellular traps that activate the coagulation contact system. Acute leukemia patients showed high levels of these traps and factor XIIa, suggesting a link between extracellular traps and coagulation abnormalities.
Area of Science:
- Hematology
- Coagulation Science
- Oncology
Background:
- Leukemic cells release nuclear contents as extracellular traps.
- These extracellular traps can activate the coagulation contact system.
- Coagulation abnormalities are observed in hematologic malignancies.
Purpose of the Study:
- To assess contact system activation, extracellular trap levels, and coagulation activation in hematologic malignancies.
- To investigate the association between extracellular traps and contact system activation in acute leukemia.
Main Methods:
- Measured coagulation factors, D-dimer, thrombin generation, extracellular trap markers (histone-DNA complex, cell-free dsDNA, leukocyte elastase), and contact system markers (factor XIIa, high-molecular-weight kininogen, prekallikrein, bradykinin) in 154 patients and 48 controls.
- Analyzed associations between these markers and specific hematologic malignancies, particularly acute leukemia.
Main Results:
- Acute leukemia patients exhibited elevated peak thrombin, extracellular trap markers, and factor XIIa levels.
- Factor XIIa levels were significantly associated with acute leukemia.
- Histone-DNA complex and cell-free dsDNA correlated with factor XIIa levels.
- Contact system activation in acute leukemia was linked to extracellular trap formation.
Conclusions:
- Extracellular traps are a likely source of contact system activation in acute leukemia.
- Contact system activation is associated with extracellular trap formation in acute leukemia.
- Targeting extracellular traps or contact system activation may offer therapeutic benefits for acute leukemia.
Keywords:
Acute leukemiaContact systemHematologic malignanciesNeutrophil extracellular trapsThrombin generation assayThrombosisMore Related Videos
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