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Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
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A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
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[Diabetes mellitus: endothelial dysfunction and changes in hemostasis].

Barna Babik1, Ferenc Peták2, Szilvia Agócs1

  • 1Aneszteziológiai és Intenzív Terápiás Intézet, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 6., 6720.

Orvosi Hetilap
|August 14, 2018
PubMed
Summary

Diabetes mellitus, a chronic metabolic disorder, significantly impacts perioperative care, especially in cardiovascular units. Understanding its prothrombotic state is crucial for managing diabetic patients undergoing surgery.

Keywords:
changes in endothelial functioncukorbetegségendothelkárosodáshemostasis imbalancetype 2 diabetesvéralvadás-egyensúlyeltolódás

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Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Hematology

Background:

  • Diabetes mellitus is a global health challenge requiring lifelong management.
  • Increasing numbers of elderly patients with diabetes undergo surgery, highlighting its perioperative significance.
  • Cardiovascular units report high diabetes incidence (30-40%), necessitating focused awareness.

Purpose of the Study:

  • To elucidate the pathophysiological mechanisms of endothelial dysfunction and prothrombotic balance in diabetes.
  • To enhance understanding of clinical considerations for perioperative care in diabetic patients.

Main Methods:

  • Review of biochemical, cellular, and organ-level changes in diabetes.
  • Analysis of metabolic milieu: hyperglycemia, insulin resistance, and lipid metabolism.
  • Examination of platelet and plasma coagulation factor alterations.

Main Results:

  • Diabetes induces endothelial dysfunction, characterized by inflammation and impaired circulation.
  • Hyperglycemia causes platelet dysfunction due to insulin-independent glucose uptake.
  • Elevated and modified coagulation factors contribute to a prothrombotic state.

Conclusions:

  • Diabetes mellitus is inherently a prothrombotic condition.
  • Understanding endothelial dysfunction and prothrombotic balance is key for perioperative management.
  • This knowledge aids in better clinical decision-making for diabetic patients during surgery.