Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.1K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.1K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.4K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.4K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

1.2K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.2K
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

963
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
963
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

560
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
560
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

576
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
576

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thyroid Function Parameters, Thyroid Status, and Vitamin B12 Deficiency in Hospitalized Adults: A Retrospective Cross-Sectional Study in Eastern India.

Cureus·2026
Same author

Coexistence of Anaemia and Common Morbidities Among Children in India Below the Age of Five Years: Evidence From the National Family Health Survey-5 (2019-21).

Cureus·2026
Same author

Pathogen-mediated priming induces intergenerational immunity against spot blotch in wheat.

World journal of microbiology & biotechnology·2026
Same author

Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Machine learning framework for cost effective deep mutational scanning through targeted substitution profiling.

BMC bioinformatics·2026
Same author

Gold nanoparticle-based electrophoresis-free colorimetric detection method for allele-specific PCR-SNP genotyping.

Analytical biochemistry·2026
Same journal

Factors associated with breastfeeding mothers' willingness to recommend human milk banks: a single-centre cross-sectional study in Türkiye.

Paediatrics and international child health·2026
Same journal

Point-of-care lactate adds to prediction of outcome in children with WHO emergency signs in a low- and middle-income setting.

Paediatrics and international child health·2026
Same journal

Variants in genes regulating thiamine metabolism in children in the Lao Thiamine study.

Paediatrics and international child health·2026
Same journal

Umbilical cord myiasis in a preterm neonate: a rare sepsis aetiology uncovered by root cause analysis - case report.

Paediatrics and international child health·2026
Same journal

A rare cause of massive haemoptysis in an adolescent.

Paediatrics and international child health·2026
Same journal

Tuberculosis presenting as an anterior chest wall swelling: three cases.

Paediatrics and international child health·2026
See all related articles

Related Experiment Video

Updated: Feb 6, 2026

A Model of Acute Lung Injury Following Visceral Ischemia-Reperfusion by Supra-Coeliac Aortic Cross Clamping in Rats
06:50

A Model of Acute Lung Injury Following Visceral Ischemia-Reperfusion by Supra-Coeliac Aortic Cross Clamping in Rats

Published on: August 15, 2025

425

Coeliac disease.

Jeremy R Glissen Brown1, Prashant Singh1

  • 1a Division of Gastroenterology and Hepatology , Beth Israel Deaconess Medical Center , Boston , Massachusetts , USA.

Paediatrics and International Child Health
|August 14, 2018
PubMed
Summary
This summary is machine-generated.

Coeliac disease (CD) is an immune response to gluten in susceptible individuals, affecting 0.7% globally. Maintaining a gluten-free diet (GFD) is crucial but challenging, with inadvertent gluten exposure causing persistent symptoms in up to 20% of patients.

Keywords:
Coeliac diseaseanaemiaatypical coeliac diseaseautoimmune disordersdiarrhoeadietglutenlow- and middle-income countries

More Related Videos

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease
03:20

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

2.4K
Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.3K

Related Experiment Videos

Last Updated: Feb 6, 2026

A Model of Acute Lung Injury Following Visceral Ischemia-Reperfusion by Supra-Coeliac Aortic Cross Clamping in Rats
06:50

A Model of Acute Lung Injury Following Visceral Ischemia-Reperfusion by Supra-Coeliac Aortic Cross Clamping in Rats

Published on: August 15, 2025

425
Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease
03:20

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

2.4K
Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.3K

Area of Science:

  • Gastroenterology
  • Immunology
  • Genetics

Background:

  • Coeliac disease (CD) is an immune-mediated disorder triggered by gluten ingestion in genetically predisposed individuals.
  • It affects approximately 0.7% of the global population, presenting a spectrum from malabsorption to asymptomatic cases.
  • Diagnosis involves detecting small intestinal villous atrophy alongside coeliac auto-antibodies or response to a gluten-free diet (GFD).

Purpose of the Study:

  • To summarize the current understanding of coeliac disease diagnosis and management.
  • To highlight the challenges and barriers patients face in adhering to a gluten-free diet (GFD).
  • To discuss the aetiologies of persistent or recurrent symptoms in patients with CD on a GFD.

Main Methods:

  • Review of current diagnostic criteria for coeliac disease (CD).
  • Analysis of guidelines regarding the avoidance of duodenal biopsies in select pediatric cases.
  • Examination of factors contributing to non-adherence and persistent symptoms in patients on a gluten-free diet (GFD).

Main Results:

  • Diagnosis of CD requires evidence of villous atrophy, auto-antibodies, or response to a GFD.
  • In some children, biopsies may be bypassed if specific symptomatic and serological criteria are met.
  • Up to 20% of CD patients experience persistent symptoms, often due to inadvertent gluten exposure, despite a GFD.

Conclusions:

  • Adherence to a gluten-free diet (GFD) is critical for managing coeliac disease (CD).
  • Understanding patient challenges in maintaining a GFD is essential for improving compliance and outcomes.
  • Further research into the triggers and management of persistent symptoms in CD is warranted.