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Updated: Feb 6, 2026

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Published on: April 10, 2019
Association of VEGFA polymorphisms with necrotizing enterocolitis in Chinese Han population
Xiaoyan Gao1, Fei Ma2, Hu Hao2
1Department of Neonatology, Southern Medical University Affiliated Maternal and Child Health Hospital of Foshan, Foshan, China.
Background:
To examine whether polymorphisms in the VEGFA gene lead to low VEGFA production in peripheral blood and increased risk of NEC in the Chinese Han population.
Material And Methods:
Thirty NEC patients and 80 control subjects were enrolled. Six VEGFA single-nucleotide polymorphisms (SNPs) were performed using the SEQUENOM MassARRAY platform assay. The concentration of VEGFA in the plasma was measured using an enzyme-linked immunosorbent assay.
Results:
The rs699947 and rs833061 VEGF-A SNPs were found to be associated with low plasma levels and high risk of NEC.
Conclusion:
Our results suggested that, if validated in larger studies, screening for VEGFA SNPs and plasma levels might be useful as a risk factor for NEC in the future.
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