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Associations Between XPD Lys751Gln Polymorphism and Leukemia: A Meta-Analysis.
Min Wen1,2,3, Bo Zhou2, Xin Lin2
1State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
Frontiers in Genetics
|August 14, 2018
Summary
Genetic variations in xeroderma pigmentosum group D (XPD) Lys751Gln polymorphisms are linked to an increased risk of leukemia. This risk is particularly pronounced in childhood and acute leukemia cases.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Xeroderma pigmentosum group D (XPD) is involved in DNA repair pathways.
- Genetic polymorphisms in DNA repair genes may influence cancer susceptibility.
- Leukemia is a significant public health concern with complex etiology.
Purpose of the Study:
- To investigate the association between xeroderma pigmentosum group D (XPD) Lys751Gln polymorphisms and leukemia risk.
- To synthesize existing evidence through a meta-analysis.
Main Methods:
- A comprehensive literature search was conducted across multiple databases.
- Meta-analysis techniques were employed, including heterogeneity and sensitivity analyses.
- Statistical models were used to calculate pooled odds ratios and assess publication bias.
Main Results:
- Fourteen studies with 7525 participants were included.
- XPD Lys751Gln polymorphisms significantly increased leukemia risk in dominant and heterozygote models.
- A borderline significant increase in risk was observed in the allele model, with consistent associations in Caucasian, adult, and chronic leukemia subgroups.
Conclusions:
- XPD Lys751Gln polymorphism is associated with an elevated risk of leukemia.
- The increased risk is particularly evident in childhood and acute leukemia cases.
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