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Treatment of pneumocystis carinii pneumonia in children

A Lipson, W C Marshall, A R Hayward

    Archives of Disease in Childhood
    |April 1, 1977
    PubMed

    Insights

    Pneumocystis pneumonia in children with underlying conditions is treatable. Pentamidine isethionate is effective but has side effects; co-trimoxazole offers a potentially safer alternative.

    Area of Science:

    • Pediatric Infectious Diseases
    • Immunology

    Background:

    • Pneumocystis carinii pneumonia (PCP) is a serious opportunistic infection.
    • Children with congenital immunodeficiency or malignancy are at high risk for PCP.

    Purpose of the Study:

    • To review treatment outcomes for pediatric PCP.
    • To evaluate the efficacy and safety of pentamidine isethionate and co-trimoxazole.

    Main Methods:

    • Retrospective review of 18 pediatric PCP cases over 16 years.
    • Analysis of treatment regimens including pentamidine isethionate and co-trimoxazole.
    • Assessment of patient outcomes and treatment-related side effects.

    Main Results:

    • 15 patients were treated; 12 recovered.
    • Untreated patients (3) died.
    • Pentamidine isethionate showed efficacy but significant side effects (hypoglycemia, uremia).
    • Co-trimoxazole appeared effective and less toxic.

    Conclusions:

    • Pentamidine isethionate is an effective treatment for pediatric PCP.
    • Co-trimoxazole is a viable, potentially safer alternative.
    • Prompt treatment is crucial for survival in immunocompromised children.

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