Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acid Strength and Molecular Structure03:05

Acid Strength and Molecular Structure

33.1K
Binary Acids and Bases
In the absence of any leveling effect, the acid strength of binary compounds of hydrogen with nonmetals (A) increases as the H-A bond strength decreases down a group in the periodic table. For group 17, the order of increasing acidity is HF < HCl < HBr < HI. Likewise, for group 16, the order of increasing acid strength is H2O < H2S < H2Se < H2Te. Across a row in the periodic table, the acid strength of binary hydrogen compounds increases with increasing...
33.1K
Strength of Cement01:20

Strength of Cement

505
Strength tests for cement are not performed directly on neat cement paste due to difficulty in obtaining consistent, reliable specimens. Instead, cement is typically tested in the form of cement-sand mortar.
For compressive strength tests, ASTM C 109-05 standards prescribe a cement-sand mix ratio of 1:2.75 and a water/cement ratio of 0.485 for making 2-inch cubes. These cubes are mixed, cast, and cured in saturated lime water at 23°C until testing. Flexural strength testing, outlined in...
505
Relation Between Tensile Strength and Compressive Strength of Concrete01:30

Relation Between Tensile Strength and Compressive Strength of Concrete

685
Concrete is a fundamental building material, and understanding its strengths is crucial for construction projects. The relationship between its tensile and compressive strengths is intricate, showing that while these strengths are related, they do not increase at the same rate. Tensile strength's growth is slower and is affected by various factors such as the methods used for testing, the size and shape of the specimen, the texture of the aggregate used, and the moisture content of the...
685
The Equilibrium Binding Constant and Binding Strength02:18

The Equilibrium Binding Constant and Binding Strength

15.1K
The equilibrium binding constant (Kb) quantifies the strength of a protein-ligand interaction. Kb can be calculated as follows when the reaction is at equilibrium:
15.1K
Strength and Heat of Hydration01:29

Strength and Heat of Hydration

707
The hydration of cement is an exothermic reaction in which heat is generated as cement hydrates. This heat of hydration is critical to cement's strength development. The rate at which this heat is generated affects the temperature rise, with a majority of the heat being released early in the hydration process, half within the first three days, and about 75% within the first week.
The heat of hydration for each cement compound is significant; for instance, tricalcium aluminate (C3A) and...
707
Fatigue Strength of Concrete01:22

Fatigue Strength of Concrete

567
Fatigue, in the context of materials science and engineering, refers to the weakening or failure of a material caused by repeatedly applied loads, even if these loads are below the strength limit of the material. Fatigue strength in concrete is a critical property that influences its durability and longevity. Concrete can fail in two ways due to fatigue. Static fatigue or creep rupture occurs under a constant load or one that increases slowly. The other failure mode is due to cyclical or...
567

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determining the pharmacologic window of bisphosphonates that mitigates severe injury-induced osteoporosis and muscle calcification, while preserving fracture repair.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021
Same author

Bone infection: a clinical priority for clinicians, scientists and educators.

European cells & materials·2021
Same author

Revisiting the "race for the surface" in a pre-clinical model of implant infection.

European cells & materials·2020
Same author

Chlorhexidine-releasing implant coating on intramedullary nail reduces infection in a rat model.

European cells & materials·2018
Same author

Substrate Modulus Regulates Osteogenic Differentiation of Rat Mesenchymal Stem Cells through Integrin β1 and BMP Receptor Type IA.

Journal of materials chemistry. B·2016
Same author

Antibiotic-loaded bone void filler accelerates healing in a femoral condylar rat model.

The bone & joint journal·2016
Same journal

Melanocortin 1 receptor-targeted peptide-functionalized liposomes for enhanced melanocyte-preferential drug delivery and anti-melanogenic efficacy.

Journal of materials chemistry. B·2026
Same journal

Recent progress in side-chain amino acid-based polymers: synthesis, self-assembly, and emerging biomedical applications.

Journal of materials chemistry. B·2026
Same journal

Bioinspired electrospun nanofibrous dressings loaded with Mentha-derived exosome-like vesicles for antibacterial and immunomodulatory burn healing.

Journal of materials chemistry. B·2026
Same journal

On demand functionality of an NIR-enhanced nanozyme catalyst for infected wound healing.

Journal of materials chemistry. B·2026
Same journal

Positively charged, phenolic hydroxyl and anthraquinone structured polystyrene microspheres targeting dual elimination of bacterial pathogens and pathogen-associated molecular patterns for sepsis therapy.

Journal of materials chemistry. B·2026
Same journal

Carbon dot-decorated Ni-MOF heterojunction sonozymes for enhanced sonodynamic-chemodynamic cancer therapy.

Journal of materials chemistry. B·2026
See all related articles

Related Experiment Video

Updated: Feb 6, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

4.2K

Resorbable Nanocomposites with Bone-Like Strength and Enhanced Cellular Activity.

S Lu1, M A P McEnery2, B R Rogers1

  • 1Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, 37235, USA.

Journal of Materials Chemistry. B
|August 14, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces novel nanocrystalline hydroxyapatite (nHA)-poly(ester urethane) (PEUR) nanocomposites for bone healing. These advanced materials offer superior mechanical strength and promote bone regeneration for weight-bearing fractures.

More Related Videos

Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites
06:34

Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites

Published on: September 19, 2020

6.4K
Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
05:57

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Published on: October 4, 2024

1.4K

Related Experiment Videos

Last Updated: Feb 6, 2026

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering
07:14

Synthesis of Graphene-Hydroxyapatite Nanocomposites for Potential Use in Bone Tissue Engineering

Published on: July 27, 2022

4.2K
Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites
06:34

Application of a Coupling Agent to Improve the Dielectric Properties of Polymer-Based Nanocomposites

Published on: September 19, 2020

6.4K
Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
05:57

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria

Published on: October 4, 2024

1.4K

Area of Science:

  • Biomaterials Science
  • Orthopedic Engineering
  • Nanotechnology

Background:

  • Bone cements for weight-bearing fractures face challenges with dynamic loading, requiring rapid setting, bone-like strength, osteogenic stimulation, and appropriate resorption.
  • Current materials often fall short of these ideal properties, with nanocrystalline hydroxyapatite (nHA) exhibiting promising osteogenic effects but poor mechanical strength.

Purpose of the Study:

  • To develop settable nanocrystalline hydroxyapatite (nHA)-poly(ester urethane) (PEUR) nanocomposites for enhanced bone healing at weight-bearing sites.
  • To overcome the mechanical limitations of nHA while leveraging its osteogenic potential.

Main Methods:

  • Synthesized nHA-PEUR nanocomposites using nHA, lysine triisocyanate (LTI), and poly(caprolactone) triol via a solvent-free process.
  • Evaluated ease of mixing and injection using a double-barrel syringe.
  • Assessed in vitro mineralization of osteoprogenitor cells and osteoclast-mediated degradation.

Main Results:

  • The nHA-PEUR nanocomposites demonstrated mechanical properties superior to conventional bone cements.
  • The materials enhanced mineralization of osteoprogenitor cells in vitro.
  • Osteoclast-mediated degradation was observed in vitro, indicating potential for biological integration.

Conclusions:

  • The developed nHA-PEUR nanocomposites offer a unique combination of settability, enhanced mechanical strength, osteogenic potential, and controlled degradation.
  • These properties position nHA-PEUR nanocomposites as a promising new approach for promoting bone healing in weight-bearing applications.