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Updated: Feb 6, 2026

Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
Acne: a side-effect of masculinizing hormonal therapy in transgender patients
C C Motosko1,2, G A Zakhem1,2, M K Pomeranz1
1Ronald O. Perelman Department of Dermatology, NYU Langone Health, New York, NY, U.S.A.
Background:
Masculinizing hormonal treatment in transgender men has the potential to increase the level of androgens at end organs, including the pilosebaceous unit. Androgen-induced sebocyte growth and differentiation, sebum production and infundibular keratinization may underlie the development of acne vulgaris among patients receiving this therapy.
Objectives:
The aim of this article is to familiarize dermatologists with the sensitivities and challenges of treating acne in transgender male individuals.
Methods:
This review article discusses the pathogenesis and treatment of acne in transgender men on testosterone therapy and highlights the unique considerations in treating this underserved patient population.
Results:
Despite the incidence of treatment-related acne and the unique considerations in treating transgender men, studies addressing this topic among this patient population are limited.
Conclusions:
Generally, the standard guidelines for the treatment of acne can be followed in treating these patients; however, several medical, social and psychological factors should be considered.
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