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Taurine abrogates mammary carcinogenesis through induction of apoptosis in Sprague-Dawley rats

Manickam Kalappan Vanitha1, Pandi Anandakumar2, Dhanapal Sakthisekaran1

  • 1Department of Medical Biochemistry, Dr. ALM PGIBMS, University of Madras, Taramani Campus, Chennai, India.

Journal of Biochemical and Molecular Toxicology
|August 14, 2018
PubMed

Insights

Taurine may protect against breast cancer by restoring apoptosis-associated protein expression. This study found taurine treatment reversed abnormalities in proteins linked to 7,12-dimethyl benz[a]anthracene (DMBA)-induced rat breast cancer.

Area of Science:

  • Oncology
  • Biochemistry
  • Molecular Biology

Background:

  • Breast cancer remains a significant challenge in oncology.
  • Apoptosis-regulating protein abnormalities are implicated in cancer progression.
  • Taurine is a biologically significant amino acid.

Purpose of the Study:

  • To investigate apoptosis-associated protein expression changes in 7,12-dimethyl benz[a]anthracene (DMBA)-induced breast cancer.
  • To evaluate the protective effects of taurine on DMBA-induced breast cancer in rats.

Main Methods:

  • Rat breast cancer was induced using 7,12-dimethyl benz[a]anthracene (DMBA).
  • DMBA-induced breast cancer-bearing rats were subsequently treated with taurine.
  • Expression levels of apoptosis-associated proteins (Bcl-2, p53, Bax, caspases) were analyzed.

Main Results:

  • DMBA-induced breast tumors showed increased Bcl-2 expression and decreased p53, Bax, and caspase expression.
  • Taurine treatment normalized the expression of these apoptosis-associated proteins.
  • Taurine administration inhibited rat breast carcinoma development.

Conclusions:

  • Aberrant apoptosis-associated protein expression is a key feature of DMBA-induced breast cancer.
  • Taurine exhibits a protective effect against breast cancer progression.
  • Taurine may exert its anti-cancer effects by inducing apoptosis.
Keywords:
7,12-dimethyl benz[a]anthraceneapoptotic regulatorsbreast cancertaurine

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